

Synthesis of octahydroquinazolinone derivatives using silica sulfuric acid as an efficient catalyst
Akbar Mobinikhaledi (1,*)



(1) Department of Chemistry, Arak University, Arak, IR-38156-879, Iran
(2) Faculty of Chemistry, Islamic Azad University, North Tehran Branch, IR1491367711, Iran
(3) Department of Chemistry, Arak University, Arak, IR-38156-879, Iran
(*) Corresponding Author
Received: 14 May 2010 | Revised: 04 Nov 2010 | Accepted: 14 Aug 2010 | Published: 22 Dec 2010 | Issue Date: December 2010
Abstract
Octahydroquinazolinone derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of silica sulfuric acid as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work-up procedure.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.1.4.291-293.108
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