European Journal of Chemistry

Synthesis of octahydroquinazolinone derivatives using silica sulfuric acid as an efficient catalyst

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Published: Dec 22, 2010
DOI: https://doi.org/10.5155/eurjchem.1.4.291-293.108
Keywords:
Quinazolinone, Silica sulfuric acid, Dimedone, Biginelli reaction
Section
Research Article
Issue
Vol. 1 No. 4 (2010): December 2010
Dates
Received 2010-05-14
Accepted 2010-08-14
Published 2010-12-22


Main Article Content

Akbar Mobinikhaledi
Department of Chemistry, Arak University, Arak, IR-38156-879, Iran
Naser Foroughifar
Faculty of Chemistry, Islamic Azad University, North Tehran Branch, IR­1491367711, Iran
Homila Khodaei
Department of Chemistry, Arak University, Arak, IR-38156-879, Iran

Abstract

Octahydroquinazolinone derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of silica sulfuric acid as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work-up procedure.

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How to Cite
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Mobinikhaledi, A.; Foroughifar, N.; Khodaei, H. Synthesis of Octahydroquinazolinone Derivatives Using Silica Sulfuric Acid As an Efficient Catalyst. Eur. J. Chem. 2010, 1, 291-293.

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