European Journal of Chemistry

Synthesis and study of antimicrobial activity of new tetralone esters

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Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.584-587.1093
Keywords:
Tetralone esters, Cyclopropanation, Antimicrobial activity, Friedel-Crafts acylation, Claisen-Schmidt reaction, Ethyl monochloro acetate
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-05-17
Accepted 2014-07-01
Published 2014-12-31


Main Article Content

Krishna Mudeenahally Hucchegowda
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Basavaraju Yeriyur Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Umesha Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Shivakumar Santhekasalagere Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India

Abstract

Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities.


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Hucchegowda, K. M.; Basavaiah, B. Y.; Basavaiah, U.; Basavaiah, S. S. Synthesis and Study of Antimicrobial Activity of New Tetralone Esters. Eur. J. Chem. 2014, 5, 584-587.

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Supporting Agencies

Central Drug Research Institute (CDRI), Lucknow and Indian Institute of Technology (IIT), Chennai, India
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