Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors

Subbarayal Reddy Dwarampudi; Gowri Sankar Dannana; Vasudeva Rao Avupati; Venkata Satyanarayana Murthy Bendi

doi:10.5155/eurjchem.5.4.570-576.1098

PDF

Published: Dec 31, 2014

DOI: https://doi.org/10.5155/eurjchem.5.4.570-576.1098

Keywords:

Hybrid molecules, Alamar blue assay, 1, 3, 5-Triaizine-chalcone, Structure activity relationship, Minimum inhibitory concentration, Mycobacterium tuberculosis H37Rv

Section

Research Article

Issue

Vol. 5 No. 4 (2014): December 2014

Dates

Received 2014-06-05
Accepted 2014-07-02
Published 2014-12-31

Subbarayal Reddy Dwarampudi

Pharmaceutical Analysis and Quality Assurance Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

Gowri Sankar Dannana

Pharmaceutical Analysis and Quality Assurance Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

Vasudeva Rao Avupati

Pharmaceutical Chemistry Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

Venkata Satyanarayana Murthy Bendi

Pharmacology Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

Abstract

A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity.

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Dwarampudi, S. R.; Dannana, G. S.; Avupati, V. R.; Bendi, V. S. M. Synthesis, Characterization and in Vitro Biological Evaluation of Some New 1,3,5-Triazine-Chalcone Hybrid Molecules As Mycobacterium Tuberculosis H37Rv Inhibitors. Eur. J. Chem. 2014, 5, 570-576.

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Supporting Agencies

Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India

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