European Journal of Chemistry

FeCl3-catalysed C-N coupling reaction between cyclic ethers and heterocyclic amines

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Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.612-617.1108
Keywords:
Catalysis, Androgenic alopecia, Anti-Cholinergic drug, FeCl3-catalysed C-N coupling, 2-Hydroxypiperidine analogs, 2-Hydroxypyrrolidine analogs
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-06-11
Accepted 2014-07-18
Published 2014-12-31


Main Article Content

Suresh Mani
Post Graduate and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Bharathidasan University, Tiruchirappalli, 620020, Tamil Nadu, India
Mashood Ahamed Fazul Mohamed
Post Graduate and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Bharathidasan University, Tiruchirappalli, 620020, Tamil Nadu, India
Abdul Khader Karakkakal
Post Graduate and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Bharathidasan University, Tiruchirappalli, 620020, Tamil Nadu, India
Syed Ali Padusha Mohamed Khan
Post Graduate and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Bharathidasan University, Tiruchirappalli, 620020, Tamil Nadu, India

Abstract

A series of 2-hydroxypyrrolidine/piperidine derivatives (4a-h)/(4i-m) were prepared by reacting 2,3-dihydrofuran (2a)/3,4-dihydro-2H-pyran (2b) with various heterocyclic amines (3a-h), using FeCl3.6H2O as catalyst. The synthesized compounds were characterized by various physic chemical techniques such as elemental analysis and spectral analysis viz, 1H NMR, 13C NMR and Mass.


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Mani, S.; Mohamed, M. A. F.; Karakkakal, A. K.; Khan, S. A. P. M. FeCl3-Catalysed C-N Coupling Reaction Between Cyclic Ethers and Heterocyclic Amines. Eur. J. Chem. 2014, 5, 612-617.

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Supporting Agencies

University Grants Commission, New Delhi, Major Research Project (Ref. No, 41-261/2012 (SR), Dated, 13-07-2012), Sophisticated Test and Instrumentation Centre (STIC), Cochin and Sophisticated Analytical Inst. Fac., Indian Institute of Technology, India
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