European Journal of Chemistry

Synthesis and biological evaluation of new quinazolinone derivatives

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Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.628-634.1120
Keywords:
Schiff bases, Azetidinone, Quinazolinone, Enzymes activities, Antioxidant activity, Antimicrobial activity
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-07-12
Accepted 2014-08-15
Published 2014-12-31


Main Article Content

Firyal Weli Asker
Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
Salma Abdul Rudha Abbas
Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
Redha Ibrahim Al-Bayati
Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
Hanaa Abd Al-Tamemi
Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq

Abstract

New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.


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How to Cite
(1)
Asker, F. W.; Abbas, S. A. R.; Al-Bayati, R. I.; Al-Tamemi, H. A. Synthesis and Biological Evaluation of New Quinazolinone Derivatives. Eur. J. Chem. 2014, 5, 628-634.

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Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
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