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Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection
Karunanidhi Lakshmi (1) , Tirumala Rajesh (2,*)
(1) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(2) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(*) Corresponding Author
Received: 20 May 2010 | Revised: 23 Jun 2010 | Accepted: 24 Jun 2010 | Published: 22 Dec 2010 | Issue Date: December 2010
Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations.
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DOI Link: https://doi.org/10.5155/eurjchem.1.4.262-265.116
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