European Journal of Chemistry 2010, 1(4), 262-265 | doi: https://doi.org/10.5155/eurjchem.1.4.262-265.116 | Get rights and content

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Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection


Karunanidhi Lakshmi (1) , Tirumala Rajesh (2,*)

(1) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(2) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(*) Corresponding Author

Received: 20 May 2010 | Revised: 23 Jun 2010 | Accepted: 24 Jun 2010 | Published: 22 Dec 2010 | Issue Date: December 2010

Abstract


Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations.

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Keywords


Voglibose; HPLC; RID; Validation; Pharmaceutical formulations

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DOI: 10.5155/eurjchem.1.4.262-265.116

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Funding information


University Grants Commission, New Delhi, India

Citations

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[1]. Masoom Raza Siddiqui, Zeid A. AlOthman, Nafisur Rahman
Analytical techniques in pharmaceutical analysis: A review
Arabian Journal of Chemistry  10, S1409, 2017
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[2]. Sanat Kumar Dash, Sasmita Kumari Acharjya, Atyurmila Chakraborty, Mitali Sahoo, Satyanarayan Tripathy, Bimala Tripathy, Ramanath Deo
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Current Pharmaceutical Analysis  18(7), 677, 2022
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Refractive Indices and Related Properties for Binary Mixtures of Methyl Acetate and Derivatives of Alkanolamines at Temperature Ranging from 293.15 to 313.15 K
ECS Journal of Solid State Science and Technology  10(4), 043001, 2021
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[4]. R. Solaichamy, J. Karpagam
Structural and Vibrational Studies (FT-IR, FT-Raman) of Voglibose Using DFT Calculation
International Letters of Chemistry, Physics and Astronomy  64, 45, 2016
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How to cite


Lakshmi, K.; Rajesh, T. Eur. J. Chem. 2010, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, K.; Rajesh, T. Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection. Eur. J. Chem. 2010, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, K., & Rajesh, T. (2010). Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection. European Journal of Chemistry, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, Karunanidhi, & Tirumala Rajesh. "Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection." European Journal of Chemistry [Online], 1.4 (2010): 262-265. Web. 3 Dec. 2022
Lakshmi, Karunanidhi, AND Rajesh, Tirumala. "Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection" European Journal of Chemistry [Online], Volume 1 Number 4 (22 December 2010)

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