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Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection
Karunanidhi Lakshmi (1)
, Tirumala Rajesh (2,*) (1) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(2) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(*) Corresponding Author
Received: 20 May 2010 | Revised: 23 Jun 2010 | Accepted: 24 Jun 2010 | Published: 22 Dec 2010 | Issue Date: December 2010
Abstract
Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations.
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DOI: 10.5155/eurjchem.1.4.262-265.116
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University Grants Commission, New Delhi, India
Citations
[1]. R. Solaichamy, J. Karpagam
Structural and Vibrational Studies (FT-IR, FT-Raman) of Voglibose Using DFT Calculation
International Letters of Chemistry, Physics and Astronomy 64, 45, 2016
DOI: 10.56431/p-7kjo7a
[2]. Masoom Raza Siddiqui, Zeid A. AlOthman, Nafisur Rahman
Analytical techniques in pharmaceutical analysis: A review
Arabian Journal of Chemistry 10, S1409, 2017
DOI: 10.1016/j.arabjc.2013.04.016
[3]. Sanat Kumar Dash, Sasmita Kumari Acharjya, Atyurmila Chakraborty, Mitali Sahoo, Satyanarayan Tripathy, Bimala Tripathy, Ramanath Deo
Application of Analytical Tools and Techniques for Estimation of a Proton Pump Inhibitor (Esomeprazole Magnesium Trihydrate): A Comprehensive Review
Current Pharmaceutical Analysis 18(7), 677, 2022
DOI: 10.2174/1573412918666220426110831
[4]. M. K. Mohammad Ziaul Hyder, Shamim Akhtar
Refractive Indices and Related Properties for Binary Mixtures of Methyl Acetate and Derivatives of Alkanolamines at Temperature Ranging from 293.15 to 313.15 K
ECS Journal of Solid State Science and Technology 10(4), 043001, 2021
DOI: 10.1149/2162-8777/abeed0
[5]. R. Solaichamy, J. Karpagam
Structural and Vibrational Studies (FT-IR, FT-Raman) of Voglibose Using DFT Calculation
International Letters of Chemistry, Physics and Astronomy 64, 45, 2016
DOI: 10.56431/p-7kjo7a
[6]. Kedar Tejashree R., A.R. Dashetwar, D.P. Kardile, A.P. Jadhav, V.C. Bhagat, R.V. Shete
Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Metformin Hydrochloride and Voglibose in Tablet Dosage form
Research Journal of Pharmacy and Technology , 3179, 2021
DOI: 10.52711/0974-360X.2021.00554
[7]. Yongjin Sung
Snapshot Holographic Optical Tomography
Physical Review Applied 11(1), , 2019
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DOI Link: https://doi.org/10.5155/eurjchem.1.4.262-265.116
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European Journal of Chemistry 2010, 1(4), 262-265 | doi: https://doi.org/10.5155/eurjchem.1.4.262-265.116 | Get rights and content
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