European Journal of Chemistry

Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides

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Published: Mar 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.1.88-92.1166
Keywords:
Synthesis, Pyridazine, Sulfonamide, Triazolopyridazine, Antimicrobial activity, Agar plate diffusion technique
Section
Research Article
Issue
Vol. 6 No. 1 (2015): March 2015
Dates
Received 2014-10-01
Accepted 2014-11-02
Published 2015-03-31


Main Article Content

Ali AbdelHamid Deeb
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Wafaa Ibrahim El-Eraky
Department of Pharmacology, National Research Centre, Dokki, Cairo, 12622, Egypt
Sebaey Mahgoub Mohamed
Research and Development Sector, Unipharma Company, El-Obour City, 11828, Egypt

Abstract

The present study describes the chemical synthesis and antimicrobial evaluation of some new pyridazine and triazolopyridazine derivatives. The structure assignments of the new compounds are based on chemical and spectroscopic evidences. The Study results showed that derivatives 6a, 6b, 6g and 6i have promising inhibitory activity against (Micrococcus luteus). Compound 6i has also noticeable inhibition activity against (Escherichia coli) and compound 3g show remarkable activity against (Candida albicans). Rest of compounds showed moderate to low activity against the examined microorganisms.


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Deeb, A. A.; El-Eraky, W. I.; Mohamed, S. M. Pyridazine and Its Related Compounds. Part 35 [1]: Synthesis, Characterization and Antimicrobial Activity of Some Novel Pyridazine and Triazolopyridazine Containing Sulfonamides. Eur. J. Chem. 2015, 6, 88-92.

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Supporting Agencies

Academy of Scientific Research and Technology, Grant no. 293/2005, Cairo, Egypt
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