European Journal of Chemistry

Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions

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Published: Jun 30, 2015
DOI: https://doi.org/10.5155/eurjchem.6.2.204-210.1252
Keywords:
3-Aminopyridazine, Anti-microbial activity, Electrophilic substitutions, Nuecleophilic substitutions, Pyaranopyrimidopyridazine, Pyrimido[1, 2-b]pyridazinone
Section
Research Article
Issue
Vol. 6 No. 2 (2015): June 2015
Dates
Received 2015-02-04
Accepted 2015-04-25
Published 2015-06-30


Main Article Content

Ali Abdel Hamid Deeb
Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
Fatma Abdel Rahman El-Mariah
Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt
Heba Kamal Abd El-Mawgoud
Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt

Abstract

A new method of generating the fused heterocyclic system with bridge head nitrogen pyrimido[1,2-b]pyridazinone, from 3-amino-4,5,6-triphenylpyridazine and malonic acid in presence of phosphoryl chloride is described. The structures of the synthesized compounds were confirmed by their infrared, mass spectrum, 1H NMR and elemental analyses. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.


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Deeb, A. A. H.; El-Mariah, F. A. R.; El-Mawgoud, H. K. A. Pyridazine and Its Related Compounds: Part 38. Pyrimido[1,2-b]pyridazinone, Synthesis and Some Reactions. Eur. J. Chem. 2015, 6, 204-210.

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