European Journal of Chemistry

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin

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Published: Dec 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.4.417-421.1310
Keywords:
Antibiotics, Amoxicillin, Schiff’s base, Condensation, Imine derivatives, Antimicrobial activity
Section
Research Article
Issue
Vol. 6 No. 4 (2015): December 2015
Dates
Received 2015-08-13
Accepted 2015-09-19
Published 2015-12-31


Main Article Content

Muhammad Islam
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
Zahid Shafiq
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
Mazhar Hussain
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
Hafiz Badaruddin Ahmad
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
Muhammad Ajaz Hussain
Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan

Abstract

Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.


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How to Cite
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Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H. B.; Hussain, M. A. Synthesis, Characterization and Antimicrobial Studies of Imine Derivatives of Amoxicillin. Eur. J. Chem. 2015, 6, 417-421.

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Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800 Pakistan
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