European Journal of Chemistry

Design and synthesis of new thiophene derivatives together with their antitumor evaluations

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Published: Dec 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.4.444-450.1316
Keywords:
Pyrazole, Thiophene, Cytotoxicity, Breast cancer, Antitumor activity, Benzo[b]thiophene
Section
Research Article
Issue
Vol. 6 No. 4 (2015): December 2015
Dates
Received 2015-09-09
Accepted 2015-10-04
Published 2015-12-31


Main Article Content

Mahmoud Ali Abdelaziz Mahmoud
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, 71491, P.O. Box 741, Kingdom of Saudi Arabia

Abstract

A series of new thiophene derivatives (3a,b) have been prepared by the reaction of acetylacetone with either cyanoacetanilide or 2-cyano-N-(p-tolyl)acetamide and elemental sulfur in the presence of triethylamine as basic catalyst. The two synthesized compounds were used to further synthesize new thiophene derivatives. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data. The antitumor activity of the newly thiophene derivatives was evaluated against six human cancer cell lines, namely gastric cancer (NUGC), colon cancer (DLD1), liver cancer (HA22T and HEPG2), nasopharyngeal carcinoma (HONE1), breast cancer (MCF) and normal fibroblast cells (WI38).


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Mahmoud, M. A. A. Design and Synthesis of New Thiophene Derivatives Together With Their Antitumor Evaluations. Eur. J. Chem. 2015, 6, 444-450.

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