European Journal of Chemistry

Design and synthesis of new thiophene derivatives together with their antitumor evaluations

Article Sidebar

PDF
Published: Dec 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.4.444-450.1316
Keywords:
Pyrazole, Thiophene, Cytotoxicity, Breast cancer, Antitumor activity, Benzo[b]thiophene
Section
Research Article
Issue
Vol. 6 No. 4 (2015): December 2015
Dates
Received 2015-09-09
Accepted 2015-10-04
Published 2015-12-31


Main Article Content

Mahmoud Ali Abdelaziz Mahmoud
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, 71491, P.O. Box 741, Kingdom of Saudi Arabia

Abstract

A series of new thiophene derivatives (3a,b) have been prepared by the reaction of acetylacetone with either cyanoacetanilide or 2-cyano-N-(p-tolyl)acetamide and elemental sulfur in the presence of triethylamine as basic catalyst. The two synthesized compounds were used to further synthesize new thiophene derivatives. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data. The antitumor activity of the newly thiophene derivatives was evaluated against six human cancer cell lines, namely gastric cancer (NUGC), colon cancer (DLD1), liver cancer (HA22T and HEPG2), nasopharyngeal carcinoma (HONE1), breast cancer (MCF) and normal fibroblast cells (WI38).


icon graph This Abstract was viewed 1627 times | icon graph Article PDF downloaded 881 times

How to Cite
(1)
Mahmoud, M. A. A. Design and Synthesis of New Thiophene Derivatives Together With Their Antitumor Evaluations. Eur. J. Chem. 2015, 6, 444-450.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Moorman, A. R.; Massink, A.; IJzerman, A. P.; Vincenzi, F.; Borea, P. A.; Varani, K. Eur. J. Med. Chem. 2015, 101, 185-204.
http://dx.doi.org/10.1016/j.ejmech.2015.06.041

[2]. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Salvador, M. K.; Preti, D.; Tabrizi, M. A.; Balzarini, J.; Nussbaumer. P.; Bassetto, M.; Brancale, A.; Fu, X. H.; Yang-Gao, Li. J.; Zhang, S. Z.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G. Bioorg. Med. Chem. 2014, 22(18), 5097-5109.
http://dx.doi.org/10.1016/j.bmc.2013.12.030

[3]. Zhang, Q.; Luo, J.; Ye, L.; Wang, H.; Huang, B.; Zhang, J.; Wu, J.; Zhang, S.; Tian, Y. J. Mol. Struct. 2014, 1074, 33-42.
http://dx.doi.org/10.1016/j.molstruc.2014.04.058

[4]. Mohareb, R. M.; Abbas, N. S.; Ibrahim, R. A. Acta Chim. Slov. 2013, 60, 583-594.

[5]. Lu, X.; Wan, B.; Franzblau, S. G.; You, Q. Eur. J. Med. Chem. 2011, 46(9), 3551-3563.
http://dx.doi.org/10.1016/j.ejmech.2011.05.018

[6]. Dalvie, D. K.; Kalgutkar, A. S.; Khojasteh-Bakht, S. C.; Obach, R. S.; O'Donnell, J. P. Chem. Res. Toxicol. 2002, 15, 269-299.
http://dx.doi.org/10.1021/tx015574b

[7]. Kagan, J.; Arora, S. K.; Prakash, I.; Ustunol, A. Heterocycles 1983, 20, 1341-1345.
http://dx.doi.org/10.3987/R-1983-07-1341

[8]. Gribble, G. W.; Saulnier, M. G.; Sibi, M. P.; Obaza-Nutaitis, J. A. J. Org. Chem. 1984, 49, 4518-4523.
http://dx.doi.org/10.1021/jo00197a039

[9]. Bakker, J.; Gommers, F. J.; Nieuwenhuis, I.; Wynberg, H. J. Biol. Chem. 1979, 254, 1841-1844.

[10]. Iyengar, S.; Arnason, J. T.; Philogene, B. J.; Murand, P.; Werstink, N. H.; Timmins, G. P. Pestic. Biochem. Physiol. 1987, 29(1), 1-9.
http://dx.doi.org/10.1016/0048-3575(87)90078-2

[11]. Matsuura, H.; Saxena, G.; Farmer, S. W.; Hancock, R. E. W.; Towers, G. H. N. Planta Med. 1996, 62, 256-259.
http://dx.doi.org/10.1055/s-2006-957872

[12]. Chan, G. F. Q.; Towers, G. H. N.; Mitchell, J. C. Phytochem. 1975, 14, 2295-2296.
http://dx.doi.org/10.1016/S0031-9422(00)91121-X

[13]. Hudson, J. B.; Graham, E. A.; Miki, N.; Towers, G. H. N.; Hudson, L. L.; Rossi, R.; Carpita, A.; Neri, D. Chemosphere 1989, 19, 1329-1343.
http://dx.doi.org/10.1016/0045-6535(89)90080-5

[14]. Malmstrom, J.; Jonsson, M.; Cotgreave, I. A.; Hammarström, L.; Sjodin, M.; Engman, L. J. Am. Chem. Soc. 2001, 123, 3434-3440.
http://dx.doi.org/10.1021/ja0035811

[15]. Nobles, W. L.; Blanton, D. W.; Jr, C. J. Pharm. Sci. 1964, 53, 115-129.
http://dx.doi.org/10.1002/jps.2600530202

[16]. Meotti, F. C.; Silva, D. O.; dos Santos, A. R. S.; Zeni, G.; Rocha, J. B. T.; Nogueira, C. W. Env. Toxicol. Pharm. 2003, 15(1), 37-44.
http://dx.doi.org/10.1016/j.etap.2003.08.008

Supporting Agencies

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).