European Journal of Chemistry

Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety

Main Article Content

Monther Faisal Mahdi
Rafah Fadhil Al-Smaism
Noor Waleed Ibrahim


An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and 1H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities.

icon graph This Abstract was viewed 1681 times | icon graph Article PDF downloaded 921 times

How to Cite
Mahdi, M. F.; Al-Smaism, R. F.; Ibrahim, N. W. Synthesis, Characterization and Antibacterial Evaluation of Novel 2-Mercaptobenzothiazole Derivatives Bearing 2-Aminonicotinonitrile Moiety. Eur. J. Chem. 2016, 7, 8-13.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Singh, V.; Kumar, P.; Sanghi, R. Prog. Polym. Sci. 2012, 37, 340-364.

[2]. Bougrin, K.; Loupy, A.; Soufiaoui, M. J. Photochem. Photobiol. C 2005, 6(2-3), 139-167.

[3]. Saxena, P.; Singh, D. C. P.; Ali, A.; Sharma, V. Int. J. Pharm. Pharm. Sci. 2013, 5(1), 454-458.

[4]. Biju, P.; McCormick, K.; Aslanian, R.; Berlin, M.; Solomon, D.; Chapman, R.; McLeod, R.; Prelusky, D.; Eckel, S.; Kelly, G.; Natiello, M.; House, A.; Fernandez, X.; Bitar, R.; Phillips, J.; Anthes, J. Bioorg. Med. Chem. 2011, 21(21), 6343-6347.

[5]. Al-Majidi, S. M. H. J. Saudi Chem. Soc. 2014, 18, 893-901.

[6]. Asrondkar, A.; Patil, V.; Mishra, N.; Bobade, A. S.; Chowdhary, A. S. World J. Pharm. Res. 2015, 4(2), 618-626.

[7]. Chugunova, E.; Boga, C.; Sazykin, I.; Cino, S.; Micheletti, G.; Mazzanti, A.; Sazykina, M.; Burilov, A.; Khmelevtsova, L.; Kostina, N. Eur. J. Med. Chem. 2015, 93, 349-359.

[8]. Dua, R.; Sonwane, S. K.; Srivastava, S. K.; Srivastava, S. D. World J. Chem. 2010, 5(1), 52-56.

[9]. Aboelmagd, A.; Ali, I. A. I.; Salem, E M. S.; Abdel-Razik M. Arkivoc 2011, 9, 337-353.

[10]. Bari, S.; Manda, S.; Ugale, V.; Jupally, V. R.; Akena, V. Indian J. Chem. B 2015, 54, 418-429.

[11]. Srivastava, S. K.; Yadav, R.; Srivastava, S. D. Indian J. Chem. B 2004, 43, 399-405.

[12]. Azam, M. A.; Suresh, B. Sci. Pharm. 2012, 80, 789-823.

[13]. Shah, A. R.; Dabhi, H. R.; Rana, A. K. Pharma Chem. 2015, 7(3), 158-162.

[14]. Alam, M. A.; Alam, M. M.; Zaman, M. S.; Khan, S. A.; Akhter, M. Int. J. Pharm. Chem. Anal. 2015, 2(2), 65-73.

[15]. Bule, S. S.; Kumbhare, M. R. Dighe, P. R. J. Chem. Bio. Phy. Sci. Sec. B 2013, 3(3), 1996-2005.

[16]. Ali, A. R.; El-Bendary, E. R.; Ghaly, M. A.; Shehata, I. A. Eur. J. Med. Chem. 2014, 75, 492-500.

[17]. Pattan, S. R.; Patel, P. V.; Athare, G. S.; Jagnar, A. B.; Nirmal, S. A.; Pattan, J. S. Bulg. Chem. Commun. 2014, 46(1), 125 - 134.

[18]. Bhadani, V. N.; Patel, P. A.; Purohit, H. D.; Purohit, D. M. Int. Lett. Chem. Phys. Astron. 2015, 50, 35-42.

[19]. Thakor, T.; Savjani, J. Int. J. Pharm. Tech. Res. 2014, 6(4), 1397-1406.

[20]. Kalaria, P. N.; Satasia, S. P.; Avalani, J. R.; Raval, D. K. Eur. J. Med. Chem. 2014, 83, 655-664.

[21]. Hamdya, N. A.; Kamel, G. M. Egypt. Pharm. J. 2012, 11, 22-30.

[22]. Abdulrasool, M. M.; Jawad, A. H.; Shneine, J. K. Int. J. Appl. Sci. Tech. 2012, 2(10), 155-164.

[23]. Bush, K.; Jacoby, G. A.; Medeiros, A. A. Antimicrob. Agents. Chemother. 1955, 39, 1211-1233.

[24]. Badahdah, K. O.; Abdel Hamid, H. M.; Noureddin, S. A. J. Heterocycl. Chem. 2015, 52, 67-74.

[25]. Al-Messri, Z. A. K. Synthesis of lubricant's additives, PhD thesis, University of Baghdad, 2013.

[26]. Al-Mutairi, A. A.; El-Baih, F. E. M.; Al-Hazimi, H. M. J. Saudi Chem. Soc. 2010, 14, 287-299.

[27]. Jensen, B. S. Acta Chim. Scand. 1959, 13, 1668-1670.

[28]. Bhasker, N.; Prashanthi, Y.; Subba Reddy, B. V. Chem. Sci. Trans. 2014, 3(1), 11-18.

[29]. Bhadani, V. N.; Patel, P. A.; Purohit, H. D.; Purohit, D. M. Int. Lett. Chem. Phys. Astron. 2015, 50, 35-42.

[30]. Safari, J.; Banitaba, S. H.; Khalili, S. D. Ultrason. Sonochem. 2012, 19, 1061-1069.

[31]. Shi, F.; Tu, S.; Fang, F.; Li, T. Arkivoc 2005, 1, 137-142.

[32]. EUCAST, Disk diffusion method for antimicrobial susceptibility testing. The European Committee on Antimicrobial Susceptibility Testing 2009, Eucast version 1.0, 1-16.

[33]. Youssef, M. M.; Amin, M. A. Molecules 2010, 15, 8827-8840.

[34]. Cockerill, F. R.; Wikler, M. A.; Alder, J.; Dudley M. N.; Thomson R. B.; Tumidge, J. D.; Patil, J. B; Hecht, D. W.; Hardy, D. L. Clinical and Laboratory Standard Institute, Wayne, PA, USA, 2012.

Supporting Agencies

Al Mustansiriyah Pharmacy College in Baghdad, Iraq
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).