European Journal of Chemistry

Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method

Article Sidebar

PDF
Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.37-41.1355
Keywords:
Validation, Methyl paraben, Pseudoephedrine HCl, HPTLC-densitometry, Carbinoxamine maleate, Pharmaceutical formulation
Section
Research Article
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-11-14
Accepted 2015-12-16
Published 2016-03-31


Main Article Content

Maha Mohamed Abdelrahman
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Eglal Abdelhameed Abdelaleem
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Nouruddin Wageih Ali
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Raghda Abdelmoneim Emam
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt

Abstract

An accurate, sensitive and selective High Performance Thin Layer Chromatography (HPTLC) method has been developed and validated for determination of carbinoxamine maleate and pseudoephedrine HCl in their binary mixture without previous separation. Chromatographic separation was performed on aluminum plates precoated with silica gel 60F254 using acetone: methanol:ethylacetate:triethylamine (5:4:2:0.2, v:v:v:v) as a developing system. The bands were scanned at 215 nm. The proposed method has been validated as per ICH guidelines and its linearity was evident in the ranges of 0.4-8.0 and 4-24 µg/ band for carbinoxamine maleate and pseudoephedrine HCl, respectively. The developed method has been applied for determination of the above mentioned drugs in their pharmaceutical formulation where no interference from methyl paraben present as excipient has been detected. Statistical comparison of the results obtained by the developed HPTLC method and those obtained by the reported HPLC method showed no significant difference between them. The developed method is sensitive, accurate and precise and can be easily used for quality control analysis of the studied drugs.


icon graph This Abstract was viewed 2358 times | icon graph Article PDF downloaded 906 times

How to Cite
(1)
Abdelrahman, M. M.; Abdelaleem, E. A.; Ali, N. W.; Emam, R. A. Simultaneous Determination of Carbinoxamine Maleate and Pseudoephedrine HCl in Their Pure Form and in Their Pharmaceutical Formulation by HPTLC-Densitometric Method. Eur. J. Chem. 2016, 7, 37-41.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Martindale: The complete drug reference, The Extra Pharmacopoeia, 35th edition, London: Pharmaceutical Press, 2007.

[2]. BP, The British Pharmacopoeia, Her Majesty's, The Stationary Office, London, 2007.

[3]. Ramadan, A. A.; Mandil, H. Anal. Biochem. 2006, 353(1), 133-137.
http://dx.doi.org/10.1016/j.ab.2006.02.020

[4]. Mosconi, L. Analyst 1968, 93, 326-327.
http://dx.doi.org/10.1039/an9689300326

[5]. Shoukrallah, I. Anal. Lett. 1991, 24(11), 2043-2058.
http://dx.doi.org/10.1080/00032719108053032

[6]. Palabiyik, I. M.; Feyyaz, O. J. Anal. Chem. 2012, 67(1), 56-63.
http://dx.doi.org/10.1134/S1061934812010066

[7]. Carina de, A. B.; Marcone, A. L. Quim. Nova 2009, 32(7), 225-228.

[8]. Gurupadayya, B. M.; Bhavani, B. G.; Sharfuddin, S. IOSR J. Appl. Chem. 2014, 6(6), 46-51.
http://dx.doi.org/10.9790/5736-0664651

[9]. Hoffman, D. J.; Leveque, M. J.; Thomson, T. J. Pharm. Sci. 1983, 72(11), 1342-1344.
http://dx.doi.org/10.1002/jps.2600721126

[10]. Hussain, K. R.; Mahesh, N.; Prasad, V. V. L. N.; Prakash, V. D. Bri. J. Pharm. Res. 2014, 4(4), 16-19.

[11]. Sahu, R.; Sharma, H. K.; Sahu, V.; Tripathi, S.; Jain, N. Int. J. Res. Pharm. & Sci. 2011, 1(3), 42-47.

[12]. Monferrer-Pons, L.; Esteve-Romero, J. S.; Ramis-Ramos, G.; Garcia-Alvarez-Coque, M. C. Anal. Lett. 1996, 29(8), 1399-1413.
http://dx.doi.org/10.1080/00032719608001490

[13]. Ali, M. S.; Ghori, M.; Rafiuddin, S.; Khatri, A. R. J. Pharm. Biomed. Anal. 2007, 43(1), 158-167.
http://dx.doi.org/10.1016/j.jpba.2006.06.038

[14]. Gu, X.; Li, H.; Macnair, K. R.; Simons, F. E.; Simons, K. J. J. Pharm. Biomed. Anal. 2005, 37(4), 663-667.
http://dx.doi.org/10.1016/j.jpba.2004.10.054

[15]. Louhaichi, M. R.; Jebali, S.; Loueslati, M. H.; Adhoum, N.; Monser, N. Talanta 2009, 78, 991-997.
http://dx.doi.org/10.1016/j.talanta.2009.01.019

[16]. Shervington, L. A. Anal. Lett. 1997, 30, 927-944.
http://dx.doi.org/10.1080/00032719708002307

[17]. Altuntas, T. G.; Zanooz, S. S.; Nebioglu, D. J. Pharm. Biomed. Anal. 1998, 17(1), 103-109.
http://dx.doi.org/10.1016/S0731-7085(97)00148-9

[18]. Leroy, A. S.; Al-Omari, M.; Abdoh, A. Saudi Pharmaceut. J. 1998, 53-59.

[19]. Mansour, A. M. J. AOAC Int. 1998, 81(5), 958-962.

[20]. Mehta, B. H.; Morge, S. B. J. Planar Chromatogr. 2008, 21(3), 173-176.
http://dx.doi.org/10.1556/JPC.21.2008.3.3

[21]. Sathe, S. R.; Bari, S. B. Acta Chromatogr. 2007, 19, 270-278.

[22]. Nouruddin, W. A.; Maha, M. A.; Eglal, A. A. J. Planar Chromatogr. 2012, 25(2), 151-156.

[23]. Hussien, E. M.; Ibrahim, M. M.; Issa, Y. M.; Abdel-Gawad, F. M.; Barakat, S. Int. J. Drug Dev. Res. 2011, 3, 168-177.

[24]. Ali, N. W.; Abdelwahab, N. S.; Abdelkawy, M.; Emam, A. A. J. Chromatogr. Sci. 2014, 52(1), 5-11.
http://dx.doi.org/10.1093/chromsci/bms197

[25]. Abdelaleem, E. A.; Abdelwahab, N. S. J. Chromatogr. Sci. 2013, 51(2), 187-191.
http://dx.doi.org/10.1093/chromsci/bms125

[26]. Wagieh, N. E.; Abbas, S. S.; Abdelkawy, M.; Abdelrahman, M. M. Drug Test. Anal. 2010, 2(3), 113-121.

[27]. Naguib, I. A.; Abdelaleem, E. A.; Zaazaa, H. E.; Hussein, E. A. E. Eur. J. Chem. 2014, 5(2), 219-226.
http://dx.doi.org/10.5155/eurjchem.5.2.219-226.966

[28]. ICH, Q2 (R1) Validation of Analytical Procedures, Proceedings of the International Conference on Harmonization, Geneva, 2005.

[29]. The United States Pharmacopeia and National Formulary, USP 30-NF, The Official Compenia of Standards, Asian Edition, The United States Pharmacopeial Convention Inc. Rockville, Md., 2007.

Supporting Agencies

Beni- Suef University, 62514, Beni-Suef, Egypt and Medical Union Pharmaceuticals Company, Egypt
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).