European Journal of Chemistry

Simultaneous determination of carbinoxamine maleate and pseudoephedrine HCl in their pure form and in their pharmaceutical formulation by HPTLC-densitometric method

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Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.37-41.1355
Keywords:
Validation, Methyl paraben, Pseudoephedrine HCl, HPTLC-densitometry, Carbinoxamine maleate, Pharmaceutical formulation
Section
Research Article
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-11-14
Accepted 2015-12-16
Published 2016-03-31


Main Article Content

Maha Mohamed Abdelrahman
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Eglal Abdelhameed Abdelaleem
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Nouruddin Wageih Ali
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt
Raghda Abdelmoneim Emam
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni- Suef University, 62514, Beni-Suef, Egypt

Abstract

An accurate, sensitive and selective High Performance Thin Layer Chromatography (HPTLC) method has been developed and validated for determination of carbinoxamine maleate and pseudoephedrine HCl in their binary mixture without previous separation. Chromatographic separation was performed on aluminum plates precoated with silica gel 60F254 using acetone: methanol:ethylacetate:triethylamine (5:4:2:0.2, v:v:v:v) as a developing system. The bands were scanned at 215 nm. The proposed method has been validated as per ICH guidelines and its linearity was evident in the ranges of 0.4-8.0 and 4-24 µg/ band for carbinoxamine maleate and pseudoephedrine HCl, respectively. The developed method has been applied for determination of the above mentioned drugs in their pharmaceutical formulation where no interference from methyl paraben present as excipient has been detected. Statistical comparison of the results obtained by the developed HPTLC method and those obtained by the reported HPLC method showed no significant difference between them. The developed method is sensitive, accurate and precise and can be easily used for quality control analysis of the studied drugs.


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Abdelrahman, M. M.; Abdelaleem, E. A.; Ali, N. W.; Emam, R. A. Simultaneous Determination of Carbinoxamine Maleate and Pseudoephedrine HCl in Their Pure Form and in Their Pharmaceutical Formulation by HPTLC-Densitometric Method. Eur. J. Chem. 2016, 7, 37-41.

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Supporting Agencies

Beni- Suef University, 62514, Beni-Suef, Egypt and Medical Union Pharmaceuticals Company, Egypt
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