European Journal of Chemistry

Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity

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Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.115-120.1387
Keywords:
HCT 116, Anticancer, Ag(I) complexes, Pd(II) complexes, Trans-metallation, N-heterocyclic carbene
Section
Research Article
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-12-20
Accepted 2016-01-09
Published 2016-03-31


Main Article Content

Abbas Washeel Salman
Department of Chemistry, College of Science, Wasit University, Kut, Wasit, 52010, Iraq
Rosenani A. Haque
The School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia

Abstract

The synthesis and characterization of two Ag(I)- N-heterocyclic carbene complexes 3 and 4 of imidazole-based NHC proligands 1 and 2, respectively, are described. The findings revealed that the choice of the counter ions is crucial, which can lead to different supramolecular architectures. Complex 3 is a trinuclear, whereas its analogue complex 4 is mononuclear. Despite being structurally different entities, these complexes form cis-palladium-NHC complex 5 by trans-metallation method, which is a cis-platinum analogue. All the reported compounds 1-5 were tested for their anticancer activities, where compounds 2 and 3 found more potent than the rest.


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Salman, A. W.; Haque, R. A. Pd(II) and Trinuclear Ag(I) Bis-N-Heterocyclic Carbene Complexes: Synthesis, Structural and in Vitro Anticancer Activity. Eur. J. Chem. 2016, 7, 115-120.

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Supporting Agencies

Universiti Sains Malaysia for the Research University Grant 1001/PKIMIA/843090, the short term grant (203/PKIMIA/6311123) and the Research University grant 1001/PKIMIA/811217.
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