European Journal of Chemistry

Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity



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Abbas Washeel Salman
Rosenani A. Haque

Abstract

The synthesis and characterization of two Ag(I)- N-heterocyclic carbene complexes 3 and 4 of imidazole-based NHC proligands 1 and 2, respectively, are described. The findings revealed that the choice of the counter ions is crucial, which can lead to different supramolecular architectures. Complex 3 is a trinuclear, whereas its analogue complex 4 is mononuclear. Despite being structurally different entities, these complexes form cis-palladium-NHC complex 5 by trans-metallation method, which is a cis-platinum analogue. All the reported compounds 1-5 were tested for their anticancer activities, where compounds 2 and 3 found more potent than the rest.


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Salman, A. W.; Haque, R. A. Pd(II) and Trinuclear Ag(I) Bis-N-Heterocyclic Carbene Complexes: Synthesis, Structural and in Vitro Anticancer Activity. Eur. J. Chem. 2016, 7, 115-120.

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Supporting Agencies

Universiti Sains Malaysia for the Research University Grant 1001/PKIMIA/843090, the short term grant (203/PKIMIA/6311123) and the Research University grant 1001/PKIMIA/811217.
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