European Journal of Chemistry

Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity

Main Article Content

Abbas Washeel Salman
Rosenani A. Haque


The synthesis and characterization of two Ag(I)- N-heterocyclic carbene complexes 3 and 4 of imidazole-based NHC proligands 1 and 2, respectively, are described. The findings revealed that the choice of the counter ions is crucial, which can lead to different supramolecular architectures. Complex 3 is a trinuclear, whereas its analogue complex 4 is mononuclear. Despite being structurally different entities, these complexes form cis-palladium-NHC complex 5 by trans-metallation method, which is a cis-platinum analogue. All the reported compounds 1-5 were tested for their anticancer activities, where compounds 2 and 3 found more potent than the rest.

icon graph This Abstract was viewed 2044 times | icon graph Article PDF downloaded 654 times icon graph Article CIF FILE downloaded 0 times icon graph Article CIF FILE downloaded 0 times

How to Cite
Salman, A. W.; Haque, R. A. Pd(II) and Trinuclear Ag(I) Bis-N-Heterocyclic Carbene Complexes: Synthesis, Structural and in Vitro Anticancer Activity. Eur. J. Chem. 2016, 7, 115-120.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Budagumpi, S.; Haque, R. A.; Endud, S.; Ur-Rehman, G.; Salman, A. W. Eur. J. Inorg. Chem. 2013, 4367-4388.

[2]. Gautier, A.; Cisnetti, F. Metallomics 2012, 4, 23-32.

[3]. Budagumpi, S.; Haque, R. A.; Salman, A. W. Coord. Chem. Rev. 2012, 256, 1787-1830.

[4]. Budagumpi, S.; Kim, K.; Kim, I. Coor. Chem. Rev. 2011, 255, 278-2809.

[5]. Liu, W.; Gust, R. Chem. Soc. Rev. 2013, 42, 755-773.

[6]. Broekemier, N. W.; Broekemier, N. C.; Short, R. T.; Palencia, H. Eur. J. Chem. 2014, 5(1), 162‐166.

[7]. Hartinger, C. G.; Dyson, P. J. Chem. Soc. Rev. 2009, 38, 391-401.

[8]. Hindi, K. M.; Panzner, M. J.; Tessier, C. A.; Cannon, C. L.; Youngs, W. J. Chem. Rev. 2009, 109, 3859-3884.

[9]. Ray, S.; Mohan, R.; Singh, J. K.; Samantaray, M. K.; Shaikh, M. M.; Panda, D.; Ghosh, P. J. Am. Chem. Soc. 2007, 129, 15042-15053.

[10]. Gao, E. J.; Liu, C.; Zhu, M. C.; Lin, H. K.; Wu, Q.; Liu, L. Anti-Cancer Agents Med. Chem. 2009, 9, 356-368.

[11]. Haque, R. A.; Salman, A. W.; Budagumpi, S.; Abdullah, A. A.; Abdul Majid, A. M. S. Metallomics, 2013, 5, 760-769.

[12]. Haque, R. A.; Salman, A. W.; Budagumpi, S.; Abdullah, A. A.; Al-Mudaris, Z. A. A.; Abdul Majid, A. M. S. Appl. Organometal. Chem. 2013, 27, 465-473.

[13]. Haque, R. A.; Salman, A. W.; Guan, T. S. Aust. J. B. Appl. Sci. 2011, 5(9), 365-370.

[14]. Haque, R. A.; Salman, A. W.; Whai, C. K.; Quah, C. K.; Fun, H. K. Acta Cryst. E 2011, 67, m97-m98.

[15]. Baker, M. V.; Brown, D. H.; Haque, R. A.; Skelton, B. W.; White, A. H. J. Incl. Phenom. Macrocycl. Chem. 2009, 65, 97-109.

[16]. Warsink, S.; de Boer, S. Y.; Jongens, L. M.; Fu, C-F.; Liu, S-T.; Chen, J-T.; Lutz, M.; Spek, A. L.; Elsevier, C. J. Dalton Trans. 2009, 7080-7086.

[17]. Dastgir, S.; Coleman, K. S.; Cowley, A. R.; Green, M. L. H. Organometallics 2006, 25, 300-306.

[18]. Magill, A. M.; McGuinness, D. S.; Cavell, K. J.; Britovsek, G. J. P.; Gibson, V. C.; White, A. J. P.; Williams, D. J.; White A. H.; Skelton, B. W. J. Organomet. Chem. 2001, 617-618, 546-560.

[19]. Wang, X.; Liu, S.; Weng, L-H.; Jin, G-X. Organometallics 2006, 25, 3565-3569.

[20]. Hsiao, T-H.; Wu, T-L.; Chatterjee, S.; Chiu, C-Y.; Lee, H. M.; Bettucci, L.; Bianchini, C.; Oberhauser, W. J. Organomet. Chem. 2009, 694, 4014-4024.

[21]. Patil, S.; Deally, A.; Gleeson, B.; Hackenberg, F.; Müller-Bunz, H.; Paradisi, F.; Tacke, M. Z. Anorg. Allg. Chem. 2011, 637, 386-396.

[22]. Patil, S.; Deally, A.; Hackenberg, F.; Müller-Bunz, H.; Paradisi, F.; Tacke, M. Metallomics 2011, 3, 74-88.

[23]. Patil, S.; Claffey, J.; Deally, A.; Hogan, M.; Gleeson, B.; Méndez, L. M. M.; Müller-Bunz, H.; Paradisi, F.; Tacke, M. Eur. J. Inorg. Chem. 2010, 1020-1031.

Supporting Agencies

Universiti Sains Malaysia for the Research University Grant 1001/PKIMIA/843090, the short term grant (203/PKIMIA/6311123) and the Research University grant 1001/PKIMIA/811217.
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).