European Journal of Chemistry

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

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Published: Sep 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.3.368-374.1443
Keywords:
Dioxime, Binuclear, Schiff base, DNA binding, DNA cleavage, Antimicrobial activity
Section
Research Article
Issue
Vol. 7 No. 3 (2016): September 2016
Dates
Received 2016-04-28
Accepted 2016-07-02
Published 2016-09-30


Main Article Content

Subramanian Vedanayaki
Department of Chemistry, Kandaswami Kandar’s College, Paramathi Velur, Tamilnadu, 638182, India
Poomalai Jayaseelan
Chemical Division, Mettur Thermal Power Station, Mettur Dam, Tamilnadu, 636406, India

Abstract

New binucleating Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of the prepared ligands with N4 donor were synthesized. The ligands are obtained by the condensation of para-phenylenediamine with diacetylmonoxime and benzilmonoxime. The synthesized ligands and their metal complexes were characterized by elemental analysis and various spectroscopic techniques. The Cu(II), Ni(II) complexes were square planar, VO(II) complex was square pyramidal, whereas Mn(II), Zn(II) complexes were of tedrahedral geometry. Both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration method. The results showed that the metal complexes were found to be more active than free ligand. The DNA binding capacities of all the complexes were analyzed by using UV absorption spectra. The DNA cleaving capacities of all complexes were analyzed by agarose gel electrophoresis method against pBR322 DNA.


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Vedanayaki, S.; Jayaseelan, P. Synthesis, Structural Characterization and Biological Properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Complexes of Tetradentate Schiff Bases. Eur. J. Chem. 2016, 7, 368-374.

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Supporting Agencies

University Grant Commission (MRP-5388/14 (SERO/UGC), March 2014, Com.code TNPE004), Hyderabad, India.
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