Utility of β-diketones in heterocyclic synthesis: Synthesis of new tetrahydro-pyrimidinethione, pyrazole, thiophene, dihydropyridine, dihydropyrane, pyridazine derivatives and investigation of their antimicrobial activity

Mohamed Ahmed Mahmoud Abdel Reheim; Ibrahim Saad Abdel Hafiz; Safaa Mohamed

doi:10.5155/eurjchem.7.3.298-308.1447

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Published: Sep 30, 2016

DOI: https://doi.org/10.5155/eurjchem.7.3.298-308.1447

Keywords:

Pyrazole, Thiophene, β-Diketones, Dihydropyridine, Antimicrobial activity, Tetrahydropyrimidinethione

Section

Research Article

Issue

Vol. 7 No. 3 (2016): September 2016

Dates

Mohamed Ahmed Mahmoud Abdel Reheim

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Ibrahim Saad Abdel Hafiz

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Safaa Mohamed

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Abstract

A series of many important diverse number of fused heterocyclic systems were prepared from the reaction of 1-(2-hydroxynaphthalen-1-yl)-3-phenylpropane-1,3-dione with some bifunctional nucleophiles, these reactions mainly proceed via condensation of 1-(2-hydroxynaphthalen-1-yl)-3-phenylpropane-1,3-dione with the aldehydic function followed by nucleophilic attack. Structures of the new compounds were established by elemental analyses and spectral data. Some of the products were also screened in vitro for their antimicrobial activity.

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Reheim, M. A. M. A.; Hafiz, I. S. A.; Mohamed, S. Utility of β-Diketones in Heterocyclic Synthesis: Synthesis of New Tetrahydro-Pyrimidinethione, Pyrazole, Thiophene, Dihydropyridine, Dihydropyrane, Pyridazine Derivatives and Investigation of Their Antimicrobial Activity. Eur. J. Chem. 2016, 7, 298-308.

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