European Journal of Chemistry 2016, 7(4), 397-404 | doi: https://doi.org/10.5155/eurjchem.7.4.397-404.1478 | Get rights and content






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Searching for anti-hyperglycemic phytomolecules of Tecoma stans


Mohamed Abdel-Hamid Taher (1,*) , Dawood Hosni Dawood (2) , Mostafa Ibrahim Sanad (3) , Ramadan Ahmed Hassan (4)

(1) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(2) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(3) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(4) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(*) Corresponding Author

Received: 18 Jul 2016 | Revised: 30 Aug 2016 | Accepted: 03 Sep 2016 | Published: 31 Dec 2016 | Issue Date: December 2016

Abstract


Tecoma stans plant is well postulated to decrease blood glucose level, but its mode of action and the molecules responsible are still controversial. Thus, the aim of this study was to evaluate the effect of leaves methanol extract of Tecoma stans and some of its fractions on starch tolerance in healthy rats, in vitro inhibition of α-amylase, and their effects of sub-chronic administration of glucose, lipid pattern, kidney and liver functions and antioxidant status in streptozotocin (STZ) induced diabetic rats. In starch tolerance experiment, both ethyl acetate and crude flavonoids fractions decreased glycemic peak values in healthy rats to extent similar to that of acarbose. In STZ sub-chronic experiment all preparations of Tecoma stans significantly decreased fasting glucose with variable degrees. The results indicated that the crude methanol extract had the most antidiabetic potential followed by the methylene chloride rich alkaloid fraction while the crude flavonoids fraction achieved the lowest effect. All Tecoma stans different preparations have positive effects on serum lipid pattern, kidney and liver function parameters, in addition to the antioxidant parameters (MDA and GSH) in liver tissues. In conclusion, the present study suggested that the alkaloids synergistically act as antidiabetic agent with other bioactive compounds of Tecoma stans especially flavonoids as hypoglycemic agents and the ethyl acetate fraction had the most powerful effects.


Keywords


Lipid pattern; HPLC analysis; Tecoma stans L.; STZ-induced rats; Anti α-amylase activity; Antioxidant parameters

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DOI: 10.5155/eurjchem.7.4.397-404.1478

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Funding information


Mansoura University, Mansoura, 33516, Egypt

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How to cite


Taher, M.; Dawood, D.; Sanad, M.; Hassan, R. Eur. J. Chem. 2016, 7(4), 397-404. doi:10.5155/eurjchem.7.4.397-404.1478
Taher, M.; Dawood, D.; Sanad, M.; Hassan, R. Searching for anti-hyperglycemic phytomolecules of Tecoma stans. Eur. J. Chem. 2016, 7(4), 397-404. doi:10.5155/eurjchem.7.4.397-404.1478
Taher, M., Dawood, D., Sanad, M., & Hassan, R. (2016). Searching for anti-hyperglycemic phytomolecules of Tecoma stans. European Journal of Chemistry, 7(4), 397-404. doi:10.5155/eurjchem.7.4.397-404.1478
Taher, Mohamed, Dawood Hosni Dawood, Mostafa Ibrahim Sanad, & Ramadan Ahmed Hassan. "Searching for anti-hyperglycemic phytomolecules of Tecoma stans." European Journal of Chemistry [Online], 7.4 (2016): 397-404. Web. 30 Nov. 2020
Taher, Mohamed, Dawood, Dawood, Sanad, Mostafa, AND Hassan, Ramadan. "Searching for anti-hyperglycemic phytomolecules of Tecoma stans" European Journal of Chemistry [Online], Volume 7 Number 4 (31 December 2016)

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