Microwave assisted multicomponent reaction: An environmentally benign protocol for the synthesis of substituted imidazo[2,1-b]thiazole-2-carbohydrazide derivatives under solvent free condition | European Journal of Chemistry

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Published: Dec 31, 2016

DOI: https://doi.org/10.5155/eurjchem.7.4.431-435.1485

Keywords:

Thiazole, Imidazol, Microwave, Carbohydrazide, Multi-component, Solvent free reaction

Section

Research Article

Issue

Vol. 7 No. 4 (2016): December 2016

Dates

Received 2016-08-08
Accepted 2016-10-01
Published 2016-12-31

Shuddhodan Narhari Kadam

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Ajay Niwruttirao Ambhore

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Milind Vithalrao Gaikwad

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Rahul Datta Kamble

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Amruteshwar Arts, Commerce and Science College, Vinzar, Tal. Velhe Dist., Pune, 412213, India

Shrikant Vasantappa Hese

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Madhav Janardan Hebade

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Bhaskar Sadashiv Dawane

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School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431606, India

Abstract

The present report describes a microwave assisted convenient and efficient protocol for the synthesis of new 6-(4-substituted-phenyl)-3-methylimidazo[2,1-b]thiazole-2-carbohydra- zide derivatives. The current method holds a tag of green synthesis by virtue of catalyst and solvent free media. Moreover, the procedure offers excellent yield and purity of the products under mild condition compared with conventional method.

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Kadam, S. N.; Ambhore, A. N.; Gaikwad, M. V.; Kamble, R. D.; Hese, S. V.; Hebade, M. J.; Dawane, B. S. Microwave Assisted Multicomponent Reaction: An Environmentally Benign Protocol for the Synthesis of Substituted imidazo[2,1-b]thiazole-2-Carbohydrazide Derivatives under Solvent Free Condition. Eur. J. Chem. 2016, 7, 431-435.

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Supporting Agencies

The University Grants Commission (F. No. 38-07/14 WRO), (F. No. 36-33/14 WRO) and (F. No. 31-21/14 WRO).

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