European Journal of Chemistry

Synthesis, antibacterial activities and phospholipid membrane interactions of novel dialkyl 2,2’-disulfanediyldibenzoates

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Published: Mar 31, 2017
DOI: https://doi.org/10.5155/eurjchem.8.1.60-65.1540
Keywords:
Lipophilicity, Dithiosalicylic acid, Dithio-bis-benzoates, Antibacterial activity, Phospholipid binding, X-ray crystallography
Section
Research Article
Issue
Vol. 8 No. 1 (2017): March 2017
Dates
Received 2016-12-30
Accepted 2017-01-25
Published 2017-03-31


Main Article Content

Sabina Jhaumeer Laulloo
Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
Minu Gupta Bhowon
Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
Matthew Akerman
University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africaa
Nausheen Joondan
Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
Marie Jessika Momus
Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius

Abstract

A series of dialkyl 2,2’-disulfanediyldibenzoates with alkyl chain length C8 to C12 were synthesized and characterized by spectral studies. The structure of compound 3 was also confirmed by X-ray crystallography. The compounds were found to possess good antibacterial activity, especially with respect to Gram positive bacteria, and the activity was found to increase with concomitant increase in chain length. Binding studies of compound 3 with the synthetic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) showed that the compound interacts with biological membrane mainly via hydrophobic interactions.


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Laulloo, S. J.; Bhowon, M. G.; Akerman, M.; Joondan, N.; Momus, M. J. Synthesis, Antibacterial Activities and Phospholipid Membrane Interactions of Novel Dialkyl 2,2’-Disulfanediyldibenzoates. Eur. J. Chem. 2017, 8, 60-65.

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University of Mauritius, Reduit 80837, Mauritius
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