

Synthesis, antibacterial activities and phospholipid membrane interactions of novel dialkyl 2,2’-disulfanediyldibenzoates
Sabina Jhaumeer Laulloo (1,*)





(1) Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
(2) Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
(3) University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africaa
(4) Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
(5) Department of Chemistry, Faculty of Science, University of Mauritius, Reduit 80837, Mauritius
(*) Corresponding Author
Received: 30 Dec 2016 | Accepted: 25 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017
Abstract
A series of dialkyl 2,2’-disulfanediyldibenzoates with alkyl chain length C8 to C12 were synthesized and characterized by spectral studies. The structure of compound 3 was also confirmed by X-ray crystallography. The compounds were found to possess good antibacterial activity, especially with respect to Gram positive bacteria, and the activity was found to increase with concomitant increase in chain length. Binding studies of compound 3 with the synthetic phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) showed that the compound interacts with biological membrane mainly via hydrophobic interactions.
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DOI: 10.5155/eurjchem.8.1.60-65.1540
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University of Mauritius, Reduit 80837, Mauritius
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DOI Link: https://doi.org/10.5155/eurjchem.8.1.60-65.1540

















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