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A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives
Shashikala Kethireddy (1)
, Hemalatha Kotakommula (2) , Laxminarayana Eppakayala (3) , Thirumala Chary Mariganti (4,*) (1) Geethanjali College of Engineering and Technology, Keesara, Rangareddy, 501301, Telangana, India
(2) Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, Telangana, India
(3) Sreenidhi Institute of Science and Technology, Ghatkesar, Hyderabad, 501301, Telangana, India
(4) Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, Telangana, India
(*) Corresponding Author
Received: 11 Feb 2017 | Revised: 19 Mar 2017 | Accepted: 19 Mar 2017 | Published: 30 Jun 2017 | Issue Date: June 2017
Abstract
Newly synthesized compounds containing quinoxaline ring fused with tetrazoles and oxadiazoles show array of pharmacological activities, especially, anti-inflammatory, analgesic and anticonvulsant activities. The ability to serve as surrogates or bioisosteres for carboxylic acids, esters and carboxamides made them important moieties in drug designing. Considering the importance of quinoxalines, tetrazoles and 1,3,4-oxadiazoles to both medicinal and heterocyclic chemistry, the following 2-((5-aryl-1,3,4-oxadiazol-2-yl)methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives are synthesized. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and Mass spectral data. All the synthesized derivatives were tested in vitro for their antibacterial activity.
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DOI: 10.5155/eurjchem.8.2.125-129.1553
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Geethanjali College of Engineering and Technology, Keesara, Rangareddy, 501301, Telangana, India
Citations
[1]. Rogy R. Ezz Eldin, Ahmed A. Al-Karmalawy, Mohammad Hayal Alotaibi, Marwa A. Saleh
Quinoxaline derivatives as a promising scaffold for breast cancer treatment
New Journal of Chemistry 46(21), 9975, 2022
DOI: 10.1039/D2NJ00050D
References
[1]. Bekhit, A. A.; El-Sayed, O. A.; El-Sayedi, A.; Park, J. Y. Eur. J. Med. Chem. 2004, 39, 249-255.
https://doi.org/10.1016/j.ejmech.2003.12.005
[2]. Smita, S.; Sharma, M. C.; Kohli, D. V. J. Optoelect. Biomed. Mat. 2010, 1(3), 151-160.
[3]. Mohite, P. B.; Bhaskar, V. H. Int. J. Pharm. Tech. Res. 2011, 3, 1557-1566.
[4]. Wagle, S.; Adhikari, A. V.; Kumari, S. K. Eur. J. Med. Chem. 2009, 44, 1135-1143.
https://doi.org/10.1016/j.ejmech.2008.06.006
[5]. Upadhayaya, R. S.; Jain, S.; Sinha, N.; Kishore, N.; Chandra, R.; Arora, S. K. Eur. J. Med. Chem. 2004, 39, 579-592.
https://doi.org/10.1016/j.ejmech.2004.03.004
[6]. Matysiak, J.; Niewiadomy, A.; Krajewska-Kulak, E.; Niewiadomy, M. G. Il Farmaco 2003, 58, 455-461.
https://doi.org/10.1016/S0014-827X(03)00046-6
[7]. Popat, B. M.; Vaidhun, H. B. Orbital-Elec. J. Chem. 2010, 3, 311-315.
[8]. Rajasekaran, A.; Thampi, P. P. Eur. J. Med. Chem. 2004, 39, 273-279.
https://doi.org/10.1016/j.ejmech.2003.11.016
[9]. Rajasekaran, A.; Thampi, P. P. Eur. J. Med. Chem. 2005, 40, 1359-1364.
https://doi.org/10.1016/j.ejmech.2005.07.013
[10]. Bhaskar, V. H.; Mohite, P. B. J. Optoelect. Biomed. Mat. 2010, 2(4), 249-259.
[11]. Pattan, S. R.; Kekare, P.; Patil, A.; Nikalge, A.; Kittur, B. S. Iran J. Pharm. Sci. 2009, 5(4), 225-230.
[12]. Basheer, H. A.; Aveen, A. I.; Maysoon, S. A. J. Pure Appl. Chem. 2016, 2(1), 1-3.
[13]. Navidpour, L.; Amini, M.; Shafaroodi, H.; Abdi, K.; Ghahremani, M. H.; Dehpour, A. R.; Shafiee, A. Bioorg. Med. Chem. Lett. 2006, 15, 4483-4487.
https://doi.org/10.1016/j.bmcl.2006.06.032
[14]. Gao, Y. L.; Zhao, G. L.; Liu, W.; Shao, H.; Wang, Y. L.; Xu, W. R.; Tangand, L. D.; Wang, J. W. Indian J. Chem. B 2010, 49, 1499-1508.
[15]. Rajasekaran, A.; Rajagopal, K. A. Acta Pharm. 2009, 59, 355-364.
https://doi.org/10.2478/v10007-009-0026-7
[16]. Gundugola, A. S.; Chandra, K. L.; Perchellet, E. M.; Water, A. M.; Rayat, S. Bioorg. Med. Chem. Lett. 2010, 20, 3920-3924.
https://doi.org/10.1016/j.bmcl.2010.05.012
[17]. Sharon, A.; Pratap, R.; Tiwari, P.; Srivastava, A.; Maulik, P. R.; Vishnu, J. R. Bioorg. Med. Chem. Lett. 2005, 15, 2115-2117.
https://doi.org/10.1016/j.bmcl.2005.02.060
[18]. Umarani, N.; Kaliappan, I.; Singh, N. K. Derpharma Chem. 2010, 2(1), 159-167.
[19]. Umarani, N. K. Int. J. Pharm. Sci. Rev. Res. 2010, 2(2), 24-28.
[20]. Othman, A. A.; Mebrouk, K.; Sarah, A. Arab. J. Chem. 2014, 32, 714-725.
[21]. Oliveira, C. S.; Lira, B. F.; Barbosa-Filho, J. M.; Lorenzo, J. G. F.; Athayde-Filho, P. F. Molecules 2012, 17, 10192-10231.
https://doi.org/10.3390/molecules170910192
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DOI Link: https://doi.org/10.5155/eurjchem.8.2.125-129.1553
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European Journal of Chemistry 2017, 8(2), 125-129 | doi: https://doi.org/10.5155/eurjchem.8.2.125-129.1553 | Get rights and content
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