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Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations
Fawzia Ahmed Ibrahim (1) , Mary Elias Kamel Wahba (2) , Galal Magdy Galal (3,*)
(1) Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt
(2) Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt
(3) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 35712, Egypt
(*) Corresponding Author
Received: 19 Apr 2017 | Revised: 16 May 2017 | Accepted: 30 May 2017 | Published: 30 Sep 2017 | Issue Date: September 2017
Two new and simple spectrophotometric procedures have been proposed and validated for estimation of two important macrolide antibiotics namely, azithromycin dihydrate and roxithromycin. Method I depends on complex formation between any of the two drugs and copper in acidic medium where the absorbances of the produced complexes are measured at 250 and 264 nm with linearity ranges of 1.0-100.0 and 2.0-130.0 µg/mL for the two drugs, respectively. Method II depends on the reaction of these drugs with N-bromosuccinimide forming a product which is yellow colored, measured at 264 and 278 nm, with linearity ranges of 2.0-140.0 and 3.0-160.0 µg/mL for azithromycin dihydrate and roxithromycin, respectively. The proposed methods were subjected to detailed validation procedure; moreover they were used for the estimation of the concerned drugs in their different dosage forms. Study of the reactions stoichiometry was carried out; furthermore, a reaction mechanism proposal was presented.
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DOI Link: https://doi.org/10.5155/eurjchem.8.3.203-210.1574
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European Journal of Chemistry 2017, 8(3), 203-210 | doi: https://doi.org/10.5155/eurjchem.8.3.203-210.1574 | Get rights and content
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