European Journal of Chemistry 2011, 2(1), 94-99 | doi: | Get rights and content

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Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

Shankar Gaddeppa Alegaon (1,*) , Kallanagouda Ramappa Alagawadi (2)

(1) Department of Pharmaceutical Chemistry, Karnataka Lingayat Education University’s College of Pharmacy, Belgaum, Karnataka, IN-590010, India
(2) Department of Pharmaceutical Chemistry, Karnataka Lingayat Education University’s College of Pharmacy, Belgaum, Karnataka, IN-590010, India
(*) Corresponding Author

Received: 09 Jun 2010 | Revised: 09 Sep 2010 | Accepted: 11 Oct 2010 | Published: 28 Mar 2011 | Issue Date: March 2011


Imidazo[2,1-b][1,3,4]thiadiazoles (4a-g) were synthesized from 3,4,5-trimethoxy benzoic acid and thiosemicarbazide. Reaction of 4 with Vilsmeier-Haack reagent yielded imidazo [2,1-b][1,3,4] thiadiazole–5-carbaldehyde derivatives (5a-g). Obtained imidazo[2,1-b][1,3,4] thiadia zoles-5-carbaldehydes were subjected to Knoevenagel condensation with 2-(2,4-dioxothia zolidin-3-yl)acetic acid (1) and 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic (2) in the presence of catalytic amount of piperidine and acetic acid to afford imidazo[2,1-b][1,3,4]thiadiazoles (6a-g) and (7a-g), respectively. The structures of the newly synthesized compounds were confirmed by IR, NMR and elemental analyses. All compounds were screened for their antibacterial and antifungal activities. Some of the compounds displayed good antibacterial and antifungal activity.



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European Journal of Chemistry


Thiazolidinedione; Thiadiazole; Imidazo[2,1-b][1,3,4]thiadiazoles; Antibacterial activity; Antifungal activity; Rhodanine

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DOI: 10.5155/eurjchem.2.1.94-99.161

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How to cite

Alegaon, S.; Alagawadi, K. Eur. J. Chem. 2011, 2(1), 94-99. doi:10.5155/eurjchem.2.1.94-99.161
Alegaon, S.; Alagawadi, K. Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives. Eur. J. Chem. 2011, 2(1), 94-99. doi:10.5155/eurjchem.2.1.94-99.161
Alegaon, S., & Alagawadi, K. (2011). Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives. European Journal of Chemistry, 2(1), 94-99. doi:10.5155/eurjchem.2.1.94-99.161
Alegaon, Shankar, & Kallanagouda Ramappa Alagawadi. "Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives." European Journal of Chemistry [Online], 2.1 (2011): 94-99. Web. 24 Sep. 2023
Alegaon, Shankar, AND Alagawadi, Kallanagouda. "Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives" European Journal of Chemistry [Online], Volume 2 Number 1 (28 March 2011)

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