European Journal of Chemistry

Conductometric determination of naproxen in bulk and pharmaceutical dosage form

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Published: Dec 31, 2017
DOI: https://doi.org/10.5155/eurjchem.8.4.339-343.1614
Keywords:
Naproxen, Conductivity, Inflammation, Sodium hydroxide, Analytical methods, Pharmaceutical dosage form
Section
Research Article
Issue
Vol. 8 No. 4 (2017): December 2017
Dates
Received 2017-07-26
Accepted 2017-09-20
Published 2017-12-31


Main Article Content

Hassan Ahmad Alhazmi
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jazan University, 45142, Jazan, Kingdom of Saudi Arabia
Mohammed Al Bratty
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jazan University, 45142, Jazan, Kingdom of Saudi Arabia

Abstract

This study aimed at the development of simple and cheap conductometric method that can be used for the determination of naproxen in bulk and dosage forms. During the study, naproxen was titrated with sodium hydroxide (Method A) and potassium hydroxide (Method B) and the end points were determined with conductivity cell. Variables affecting the end point determination were also studied in the range of 1-10 mg/mL of naproxen. The proposed methods were validated by precision and recovery studies. The percentage recoveries ranged from 99.15±0.659 and 101.13±0.543 with % RSD of 0.897 and 0.749 with sodium hydroxide and potassium hydroxide, respectively. The methods were effectively applied for the determination of naproxen in tablet dosage form. The methods proposed in this study can be used as substitute for more composite and classy methods used for the determination of naproxen and are highly reproducible as compared to other reported methods.


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Alhazmi, H. A.; Al Bratty, M. Conductometric Determination of Naproxen in Bulk and Pharmaceutical Dosage Form. Eur. J. Chem. 2017, 8, 339-343.

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References

[1]. The British Pharmacopoeia, Her Majesty's Stationery Office, London, 2010.

[2]. Sweetman, S. C. Martindale: The Complete Drug Reference, 35th edition, Pharmaceutical Press, 2007.

[3]. Krakow; Practical Medicine Drug Index, Medycyna Praktyczna, 2007.

[4]. Boynton, C. S.; Dick, C. F.; Mayor, G. H. J. Clin. Pharm. 1988, 28, 512-517.
https://doi.org/10.1002/j.1552-4604.1988.tb03170.x

[5]. Khan, I. U.; Aman, T.; Ashraf, A.; Kazi A. A. Anal. Lett. 1999, 32, 2035-2050.
https://doi.org/10.1080/00032719908542950

[6]. Dokhe, M. D.; Tarkase, M. K.; Bhand, S. D.; Chitale, A. B. Int. J. Pharm. Sci. Rev. Res. 2015, 31, 72-74.

[7]. Pyka, A.; Wiatr, E.; Kwiska, K.; Gurak, D. J. Liq. Chromatogr. Relat. Technol. 2011, 34, 829-847.
https://doi.org/10.1080/10826076.2011.571152

[8]. Sun, Y.; Takaba, K.; Kido, H.; Nakashima, M. N.; Nakashima, K. J. Pharm. Biomed. Anal. 2003, 30, 1611-1619.
https://doi.org/10.1016/S0731-7085(02)00549-6

[9]. Rodriguez, I.; Quintana, J. B.; Carpinteiro, J.; Carro, A. M.; Lorenzo, R. A.; Cela, R. J. Chromatogr. A 2003, 985, 265-274.
https://doi.org/10.1016/S0021-9673(02)01528-5

[10]. Lenik, J.; Dumkiewicz, R.; Wardak, C.; Marczewska, B. Acta Pol. Pharm. 2002, 59, 171-176.

[11]. Carretero, A. S.; Blanco, C. C.; Garcia, M. R.; Diaz, B. C.; Gutierrez, A. F. Talanta 1999, 50, 401-407.
https://doi.org/10.1016/S0039-9140(99)00126-5

[12]. Damiani, P.; Bearzotti, M.; Cabezon, M. A. J. Pharm. Biomed. Anal. 2002, 29, 229-238.
https://doi.org/10.1016/S0731-7085(02)00063-8

[13]. Ibanez, G. A.; Escandar, G. M. J. Pharm. Biomed. Anal. 2005, 37, 149-155.
https://doi.org/10.1016/j.jpba.2004.10.003

[14]. Junquera, E.; Aicart, E. Int. J. Pharm. 1999, 176, 169-178.
https://doi.org/10.1016/S0378-5173(98)00313-5

[15]. Sadecka, J.; Cakrt, M.; Hercegova, A.; Polonsky, J.; Skacani, I. J. Pharm. Biomed. Anal. 2001, 25, 881-891.
https://doi.org/10.1016/S0731-7085(01)00374-0

[16]. Elsinghorst, P. W.; Kinzig, M.; Rodamer, M.; Holzgrabe, U.; Sorgel, F. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2011, 879, 1686-1696.
https://doi.org/10.1016/j.jchromb.2011.04.012

[17]. Stefano, J. S.; de-Lima. P. A.; Montes, R. H. O.; Richter, E. M.; Munoz, R. A. A. J. Braz. Chem. Soc. 2012, 23(10), 1834-1838.
https://doi.org/10.1590/S0103-50532012005000055

[18]. Magda, M. A.; Hisham, E. A.; Mervat, M. H.; Nagla, A. K. Eur. J. Chem. 2013, 4(3), 297-302.
https://doi.org/10.5155/eurjchem.4.3.297-302.811

[19]. Ashour, S.; Khateeb, M. Can. Chem. Trans. 2013, 1, 292-304.

[20]. Hasan, S. H.; Othman, N. S.; Surchi, K. M. Curr. Anal. Chem. 2016, 12, 330-334.
https://doi.org/10.2174/1573412912666151126205443

[21]. Ayad, M.; Abdellatef, H.; Hosny, M.; Kabil, N. Int. Res. J. Pharm. App. Sci. 2013, 3, 140-148.

[22]. Al-Bratty, M.; Hashem, H.; Noureldeen, A.; Manoharan, G.; Towhar, F. Int. J. Pharm. Sci. 2015, 7, 72-76.

[23]. Al-Bratty, M.; Hashem, H.; Eranhiyil, S. Int. J. Biol. Pharm. Allied Sci. 2016, 5, 93-103.

[24]. Vogel, A. J.; Textbook of quantitative inorganic analysis. Longman, 4th edition, 1978.

[25]. Lingane, J. J.; Electroanalytical Chemistry. 2nd Edition, Interscience, 1958.

[26]. Ayad, M. A.; Abdellatef, H. E.; Hosny, M. M.; Sharaf, Y. A. Eur. J. Chem. 2012, 3, 332-336.
https://doi.org/10.5155/eurjchem.3.3.332-336.637

[27]. United States Pharmacopoeia, Rockville United States Pharmacopoeial Convention, 31st Edition, 2008.

[28]. Gasilini, F.; Nahum, L. Z. Anal. Chem. 1959, 31, 989-992.
https://doi.org/10.1021/ac60150a044

[29]. Van Meurs, N.; Dahmen, E. A. M. F. Anal. Chem. 1958, 19, 64-73.

Supporting Agencies

Jazan University, 45142, Jazan, Kingdom of Saudi Arabia and Exela Pharmsci. Pvt. Ltd., Kingdom of Saudi Arabia
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