European Journal of Chemistry

Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction

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Published: Mar 31, 2018
DOI: https://doi.org/10.5155/eurjchem.9.1.44-48.1679
Keywords:
Ethanolamine, One pot reaction, Pyranoquinolinone, 4-Hydroxyquinolinone, Multicomponent reaction, Cinnamonitrile derivatives
Section
Research Article
Issue
Vol. 9 No. 1 (2018): March 2018
Dates
Received 2017-12-28
Accepted 2018-01-28
Published 2018-03-31
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Ibrahim Ali Radini
Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
https://orcid.org/0000-0003-2835-4874
Sameh Ramadan El-Gogary
Chemistry Department, Faculty of Science, Damietta University, New Damietta, 34518, Egypt
https://orcid.org/0000-0002-0465-4023
Mohamed Sabri Mostafa
Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
https://orcid.org/0000-0003-3537-3598
Bander Alnagei
Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
https://orcid.org/0000-0001-5513-7838
Mohammed Mudarbish
Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
https://orcid.org/0000-0002-5754-4995
Shadad Dash
Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
https://orcid.org/0000-0002-2602-0080

Abstract

Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.


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How to Cite
(1)
Radini, I. A.; El-Gogary, S. R.; Mostafa, M. S.; Alnagei, B.; Mudarbish, M.; Dash, S. Ecofriendly and Simple Synthesis of pyrano[3,2-c]quinolone in Water via an Efficient One-Pot Three-Component Reaction. Eur. J. Chem. 2018, 9, 44-48.

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Supporting Agencies

Jazan University (Project no. 019-FS3), Jazan, 2079, Kingdom of Saudi Arabia.
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