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A new natural pyrrolone from the Egyptian Ageratum species
Taha Abdelrahim Hussien (1)
, Naglaa Salah-Eldin Mohamed (2,*) , Mahmoud F.M. Moustafa (3) , Magdi Abdelradi El-Sayed (4) (1) Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Sciences University, Amman, 11931, Jordan
(2) Department of Chemistry, Aswan-Faculty of Science, South Valley University, Aswan, 81528, Egypt
(3) Department of Biological Sciences, College of Science, King Khalid University, Abha, 61413, Saudi Arabia
(4) Department of Biological and Environmental Sciences, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan
(*) Corresponding Author
Received: 27 Mar 2010 | Accepted: 08 Apr 2010 | Published: 15 Jun 2010 | Issue Date: June 2010
Abstract
Ageratum conyzoides L., is an annual herb with a long history of traditional medicinal uses in many countries in the world, especially in the tropical and subtropical regions. A wide range of chemical compounds including alkaloids, flavonoids, chromenes, benzofurans and terpenoids have been isolated from this species. Extracts and metabolites from this plant have been found to possess pharmacological and insecticidal activities. In continuation of our interest in the Egyptian medicinal plants, the reinvestigation of the methylenechloride extract of the air-dried aerial parts of Ageratum conyzoides afforded a new natural compound 1, pyrrolone, 5-ethoxy-1H-pyrrol-2(5H)-one, together with a known flavonoid. The structures of the compounds were determined by comprehensive NMR studies, including DEPT, COSY, HMQC, HMBC, and MS.
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DOI: 10.5155/eurjchem.1.2.140-141.17
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DOI Link: https://doi.org/10.5155/eurjchem.1.2.140-141.17
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