

A mathematical expression for tiemonium methylsulphate in its simultaneous spectrophotometric estimation with ketorolac tromethamine
Mohammad Nasir Uddin (1)



(1) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(2) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(3) Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh
(*) Corresponding Author
Received: 14 Apr 2018 | Revised: 20 May 2018 | Accepted: 22 May 2018 | Published: 30 Jun 2018 | Issue Date: June 2018
Abstract
Attempt has been made to develop a new, accurate, precise and economic spectrophotometric method for the simultaneous determination of ketorolactromethamine (KTR) and tiemoniummethylsulphate (TMS) in pharmaceutical formulation and bio-samples. It is noted that KTR shows two absorption peaks at 320 and 245 nm whereas TMS shows maximum absorption at 235 nm. In a mixture solution, peaks at 245 nm for KTR and at 235 nm for TMS are merged into a single peak at 240 nm. Hence KTR might be determined using its calibration equation constructed at 320 nm but the determination of TMS alone in their mixture measuring its absorption at 240 nm is difficult. Therefore, for the determination of TMS, a mathematical expression xT = k1.yK+T - k2.yK + k3 (y = Absorbance, x = Concentration) has been derived. This expression will give its concentration in mixture without having its absorption at 240 nm. Method has been applied to pharmaceutical and bio-samples successfully. Results have been compared to that estimated by new UPLC method developed as to validate this spectrophotometric method. The LOD and LOQ were found to be 0.25, 0.80 μg/mL for KTR and 0.31, 0.95 μg/mL for TMS, respectively.
Announcements
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).
2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).
3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF

DOI: 10.5155/eurjchem.9.2.138-146.1715
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics


References
[1]. Rang, H.; Dale, M.; Ritter, J.; Flower, R. Pharmacology, 6th Edition, Churchill Livingstone, Elsevier, 2007, 227-230
https://doi.org/10.1016/B978-0-443-06911-6.50006-2
[2]. Wang, Z.; Dsida, R.; Avram, M. J. Chromatog. B 2001, 755(1-2), 383-386.
https://doi.org/10.1016/S0378-4347(01)00134-7
[3]. Shankar, C.; Mishra, M. Acta Pharm. 2003, 53, 101-110.
[4]. Shyamala, B.; Sanmathi, B. S. Indian J. Pharm. Sci. 2001, 63, 538-540.
[5]. Bejjani, A.; Nsouli, B.; Zahraman, K.; Assi, S.; Younes, G.; Yazbi, F. Adv. Mater. Res. 2011, 324, 318-323.
[6]. Islam, M. S.; Wahiduzzaman, Islam, M. S.; Rafiquzzaman, M.; Kundu, S. K. Int. J Pharm Sci. Res. 2014, 5(2), 548-55.
[7]. Ayad, M.; El-Balkiny, M.; Hosny, M.; Metias, Y. Indian J. Advances Chem. Sci. 2016, 4(1), 85-97.
[8]. Zaaza, H. E.; Abbas, S. S.; El-Sherif, Z. A.; El-Zeany, B.; El-Haddad, D. A. J. App. Pharm. Sci. 2014, 4(1), 33-45.
[9]. Ramadan, N. K.; Abd El Halim, L. M.; El-Sanabary, H. F. A.; Salem, M. Y. Int. J. Drug Dev. Res. 2014, 6(1), 160-168.
[10]. Ramadan, N. K.; El-Halim, L. M. A.; El-Sanabary, H. F. A.; Salem, M. Y. Int. J. Advanced Res. 2014, 2(1), 366-376.
[11]. Chaudhary, R.; Gangwal, S.; Jindal, K.; Khann, a S. J. Chromatog. B 1993, 614(1), 180-184.
https://doi.org/10.1016/0378-4347(93)80240-5
[12]. Uddin, M. N.; Das, S.; Khan, S. H.; Shill, S. K.; Bhuiyan, H. R.; Karim, R. Research 2014, 1, 1237-1245.
https://doi.org/10.13070/rs.en.1.777
[13]. Logan, B.; Friel, N. P.; Peterson, K. L.; Predmore, B. B. J. Anal. Toxicol. 1995, 19, 61-64.
https://doi.org/10.1093/jat/19.2.61
[14]. Ayad, M.; El-Balkiny, M.; Hosny, M.; Metias, Y. Innovare J. Medical Sci. 2016, 4(3), 1-9.
[15]. Uddin, M. N.; Uddin, M.; Kabir, M. T.; Das, S. J. Pure App. Chem. Res. 2017, 6(2), 137-149.
[16]. Uddin, M. N.; Uddin, M.; Kabir, M. T. Indonesian J. Pharm. Sci. Tech. 2018, 5(1), 15-25.
[17]. Uddin, M. N.; Uddin, M.; Kabir, M. T.; Das, S. Pharm. Pharmacol. Int. J. 2017, 5(2), 117-124.
[18]. ICH Harmonized Tripartite (1996) Validation of Analytical Procedures: Text and Methodology Q2 (R1), Current Step 4 Version, Parent Guidelines on Methodology Dated November 6 1996, Incorporated In: International Conference on Harmonization, Geneva, Switzerland, 2005.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.9.2.138-146.1715

















European Journal of Chemistry 2018, 9(2), 138-146 | doi: https://doi.org/10.5155/eurjchem.9.2.138-146.1715 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Authors

This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.