European Journal of Chemistry

Polyethylene glycol (PEG-400) mediated synthesis of quinoxalines

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Published: Sep 29, 2010
DOI: https://doi.org/10.5155/eurjchem.1.3.228-231.172
Keywords:
α-Halo ketones, o-Phenylenediamines, Quinoxalines, Catalyst-free, Polyethylene glycol, PEG-400
Section
Short Communication
Issue
Vol. 1 No. 3 (2010): September 2010
Dates
Received 2010-06-17
Accepted 2010-08-10
Published 2010-09-29


Main Article Content

Lingaiah Nagarapu
Organic Chemistry Division-II, Indian Institute of Chemical Technology, Uppal Road, Hyderabad-500007, India
Raghu Mallepalli
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India
Glory Arava
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India
Lingappa Yeramanchi
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

Abstract

A simple and highly efficient protocol for the synthesis of quinoxaline derivatives from various ortho-phenylenediamines with α-halo ketones under catalyst free conditions is reported by using polyethylene glycol (PEG-400) as an efficient recyclable medium without using any organic co-solvent or additive. This protocol gives wide range of quinoxaline derivatives with high yields.

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Nagarapu, L.; Mallepalli, R.; Arava, G.; Yeramanchi, L. Polyethylene Glycol (PEG-400) Mediated Synthesis of Quinoxalines. Eur. J. Chem. 2010, 1, 228-231.

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