Microwave assisted one pot conversion of aromatic aldehydes to nitriles

Yousef Mohammad Hijji; Rajeesha Rajan; Hani Darwish Tabba; Imad Ali Abu-Yousef; Said Mansour; Hamdi Ben Yahia

doi:10.5155/eurjchem.9.3.269-274.1751

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Published: Sep 30, 2018

DOI: https://doi.org/10.5155/eurjchem.9.3.269-274.1751

Keywords:

Aldoxime, Aldehyde, Aryl nitrile, Microwave, Elimination, Hydroxylamine

Section

Research Article

Issue

Vol. 9 No. 3 (2018): September 2018

Dates

Received 2018-05-31
Accepted 2018-07-28
Published 2018-09-30

Yousef Mohammad Hijji

Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar

http://orcid.org/0000-0002-4116-1746

Rajeesha Rajan

Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar

http://orcid.org/0000-0002-8798-8992

Hani Darwish Tabba

Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar

http://orcid.org/0000-0002-5313-6951

Imad Ali Abu-Yousef

Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, 26666, Sharjah, United Arab Emirates

http://orcid.org/0000-0002-5176-3599

Said Mansour

Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, 34110 Doha, Qatar

http://orcid.org/0000-0001-8700-2874

Hamdi Ben Yahia

Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, 34110 Doha, Qatar

http://orcid.org/0000-0001-6577-9498

Abstract

Nitriles are versatile organic precursors in organic synthesis and have numerous applications. An efficient microwave assisted method for conversion of aromatic aldehydes to the corresponding nitriles is reported. Aldehydes are readily converted to oxime followed by acetylation and acetic acid elimination to provide nitriles in good yields within minutes. The method proved to be efficient for the synthesis of aromatic and heterocyclic nitriles. The reaction proceeds smoothly by microwave at 150 °C for 5 minutes. The obtained products are isolated simply by filtration or extraction.

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How to Cite

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Hijji, Y. M.; Rajan, R.; Tabba, H. D.; Abu-Yousef, I. A.; Mansour, S.; Yahia, H. B. Microwave Assisted One Pot Conversion of Aromatic Aldehydes to Nitriles. Eur. J. Chem. 2018, 9, 269-274.

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Supporting Agencies

Qatar National Research Fund (Award NPRP-7-495-1-094), Qatar

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