European Journal of Chemistry

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

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Published: Jun 30, 2019
DOI: https://doi.org/10.5155/eurjchem.10.2.166-170.1851
Keywords:
Recyclability, Zn(L-proline)2, Pyrans synthesis, Lewis acid catalyst, Environmentally friendly nature, Domino three-component reaction
Section
Research Article
Issue
Vol. 10 No. 2 (2019): June 2019
Dates
Received 2019-03-24
Accepted 2019-05-20
Published 2019-06-30
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Fatma Ahmed Abo Elsoud
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61768, Egypt
http://orcid.org/0000-0002-3650-0379
Mohamed Abd-Elmonem
Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
http://orcid.org/0000-0002-4808-1650
Mohamed Abo Elsebaa
Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
http://orcid.org/0000-0001-8810-9438
Kamal Usef Sadek
Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
http://orcid.org/0000-0003-4342-5394

Abstract

Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.


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Abo Elsoud, F. A.; Abd-Elmonem, M.; Abo Elsebaa, M.; Sadek, K. U. Zn(L-proline)2: An Efficient and Reusable Organocatalyst for the Synthesis of Polyfunctionally Substituted Pyrans and 2-Amino-4-Aryl-8-Oxo-4,8-dihydropyrano[3,2-b]pyran Derivatives. Eur. J. Chem. 2019, 10, 166-170.

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Deraya University, Minia 61768, Egypt
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