Synthesis, characterization and biological activity of a Schiff base derived from o-amino benzoic acid and its Co(II), Cd(II) and Ni(II) complexes

Tasneem Ibrahim Hussein; Musa Abduelrahman Ahmed; Ismail Adam Arbab; Awad Salim Ibrahim; Mohamed Al-Bratty; Hassan Ahmed Alhazmi; Asim Najmi

doi:10.5155/eurjchem.11.1.15-20.1941

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Published: Mar 31, 2020

DOI: https://doi.org/10.5155/eurjchem.11.1.15-20.1941

Keywords:

Complex, Schiff base, Antifungal activity, Antibacterial activity, Bidentate complexing agent, 4(1H-Imidazole-yl)acetophenoneanthranilic acid

Section

Research Article

Issue

Vol. 11 No. 1 (2020): March 2020

Dates

Received 2019-11-18
Accepted 2019-12-27
Published 2020-03-31

Tasneem Ibrahim Hussein

Department of Chemistry and Biology, Faculty of Education, University of Albutana, Gezira State, Rufaa, 22216, Sudan

http://orcid.org/0000-0002-1646-2715

Musa Abduelrahman Ahmed

Department of Chemistry and Biology, Faculty of Education, University of Gezira, Gezira State, Wad Madani, 21111, Sudan

http://orcid.org/0000-0001-7921-8114

Ismail Adam Arbab

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia

http://orcid.org/0000-0001-5811-501X

Awad Salim Ibrahim

Department of Chemistry, Faculty of Education, West Kordufan University, West Kordufan State, El-Nuhud, 55511, Sudan

http://orcid.org/0000-0002-2948-7049

Mohamed Al-Bratty

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia

http://orcid.org/0000-0001-8687-0573

Hassan Ahmed Alhazmi

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia

http://orcid.org/0000-0002-9647-9006

Asim Najmi

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia

http://orcid.org/0000-0002-7529-5523

Abstract

Equimolar amounts of imidazoleacetophenone and 2-aminobenzoic acid were combined together and the Schiff base 4(1H-imidazole-yl)acetophenoneanthranilic acid was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with cobalt(II), cadmium(II), and nickel(II) ions yielding air stable complexes. For quantification and characterization purposes, elemental analysis, infrared spectra, electronic spectra, proton nuclear magnetic resonance spectra and mass spectra studies were carried out on the obtained complexes and ligand. Thermogravimetric analysis and magnetic susceptibility measurements were also used for characterization. The ligand IR spectrum showed that the ligand acts as a bidentate coordinates to the metal ions through the nitrogen and oxygen atoms.Measurements of magnetic susceptibility for Ni(II) and Co(II) complexes were found to be 3.4 and 3.8 B.M., respectively, in the range normal for the octahedral geometry. The conductivity measurements revealed that the chelates are non-electrolytes. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against a number of bacterial and fungal strains, to assess their antimicrobial properties by diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.

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How to Cite

(1)

Hussein, T. I.; Ahmed, M. A.; Arbab, I. A.; Ibrahim, A. S.; Al-Bratty, M.; Alhazmi, H. A.; Najmi, A. Synthesis, Characterization and Biological Activity of a Schiff Base Derived from O-Amino Benzoic Acid and Its Co(II), Cd(II) and Ni(II) Complexes. Eur. J. Chem. 2020, 11, 15-20.

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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.

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