European Journal of Chemistry

Spectrum subtraction method for simultaneous determination of acetaminophen and caffeine in panadol extra dosage forms

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Published: Mar 31, 2020
DOI: https://doi.org/10.5155/eurjchem.11.1.80-83.1956
Keywords:
Caffeine, ICH guidelines, Acetaminophen, Spectrophotometric, Spectrum subtraction, Statistical comparison
Section
Research Article
Issue
Vol. 11 No. 1 (2020): March 2020
Dates
Received 2019-12-30
Accepted 2020-02-25
Published 2020-03-31
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Main Article Content

Mahmoud Mohammed Sebaiy
Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
http://orcid.org/0000-0002-5949-2834
Amr Abd El-Hakeem Mattar
Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt
http://orcid.org/0000-0001-7004-8737

Abstract

A simple, specific, accurate and precise spectrophotometric method was established for simultaneous determination of acetaminophen and caffeine in pure form and in their pharmaceutical formulation commercially known as Panadol Extra®. Spectrum subtraction has been used in simultaneous determination of both drugs without prior separation. Spectrum subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits (98-102%). The linearity range was 7.5-45 µg/mL for caffeine and 4-22 µg/mL for acetaminophen with correlation coefficients ≥0.9990 for both drugs. Advantages and disadvantages of spectrum subtraction were discussed and statistical comparison between the proposed method and the reference one was performed.


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Sebaiy, M. M.; Mattar, A. A. E.-H. Spectrum Subtraction Method for Simultaneous Determination of Acetaminophen and Caffeine in Panadol Extra Dosage Forms. Eur. J. Chem. 2020, 11, 80-83.

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