European Journal of Chemistry

Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors

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Published: Sep 30, 2020
DOI: https://doi.org/10.5155/eurjchem.11.3.198-205.1988
Keywords:
Synthesis, 1, 2, 4-Triazine, Pyrimido-[1, 2-b]-[1, 4]triazine, [1, 3, 5]-Triazino[1, CDK2 enzymatic inhibitors evaluation, Fluorinated fused heterocyclic systems
Section
Research Article
Issue
Vol. 11 No. 3 (2020): September 2020
Dates
Received 2020-04-04
Accepted 2020-05-29
Published 2020-09-30
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Main Article Content

Dina Bakhotmah
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia
http://orcid.org/0000-0001-6651-7932
Fatimah Alotaibi
Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, 71941, Saudi Arabia
http://orcid.org/0000-0003-2417-7735

Abstract

New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15.


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Bakhotmah, D.; Alotaibi, F. Synthesis and Pharmacological Evaluation of New Fluorine Substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-Triazino-[1,2-b][1,2,4]triazines Derived As CDK2 Potential Inhibitors. Eur. J. Chem. 2020, 11, 198-205.

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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia.
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