European Journal of Chemistry

Chitosan as an eco-friendly heterogeneous catalyst for Michael type addition reactions. A simple and efficient route to pyridones and phthalazines

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Published: Dec 22, 2010
DOI: https://doi.org/10.5155/eurjchem.1.4.252-258.211
Keywords:
Chitosan, Enaminone, Michael addition, Pyridone, Pthalazine, Benzylidene
Section
Research Article
Issue
Vol. 1 No. 4 (2010): December 2010
Dates
Received 2010-07-21
Accepted 2010-07-25
Published 2010-12-22


Main Article Content

Khaled Khalil
Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
Hamad Al-Matar
Chemistry Department, Faculty of Science, University of Kuwait, KW-13060, Kuwait
Mohamed Elnagdi
Chemistry Department, Faculty of Science, University of Kuwait, KW-13060, Kuwait

Abstract

Depending on their nature, nitrile activated methylene compounds add readily to β-enaminones in presence of chitosan to yield dienamides, pyridones or pyridine thiones. The dienamides, formed in this manner, can be readily converted to pyridones by stirring in refluxing acetic acid. Reaction of pyridazinones with a mixture containing benzaldehyde, malononitrile and chitosan affords phthalazines that are also produced by reaction of pyridazinone with benzylidene-malononitrile.

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Khalil, K.; Al-Matar, H.; Elnagdi, M. Chitosan As an Eco-Friendly Heterogeneous Catalyst for Michael Type Addition Reactions. A Simple and Efficient Route to Pyridones and Phthalazines. Eur. J. Chem. 2010, 1, 252-258.

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