European Journal of Chemistry 2021, 12(3), 340-359 | doi: https://doi.org/10.5155/eurjchem.12.3.340-359.2126 | Get rights and content

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Synthesis, reactions and applications of naphthofurans: A review


Ashraf Hassan Fekry Abdelwahab (1,*) orcid , Salma Ashraf Hassan Fekry (2) orcid

(1) Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Saudi Arabia
(2) Faculty of pharmacy, German university, in Cairo (GUC), Cairo, Egypt
(*) Corresponding Author

Received: 11 May 2021 | Revised: 27 May 2021 | Accepted: 17 Jun 2021 | Published: 30 Sep 2021 | Issue Date: September 2021

Abstract


Considering the highly important biological and medicinal properties of naphthofurans, the synthesis of these heterocycles has attracted the interest of medicinal and organic chemists. This review aims to describe the different strategies developed so far for the synthesis of naphthofurans and their applications and the literature reports for the period of 2000 to early 2020. After a brief introduction of the types of naphthofurans and their biological activities, the different synthetic approaches such as chemical and photochemical, methods are described and organized on the basis of the catalysts and the other reagents employed in the syntheses. Some of the reactions have been applied successfully to the synthesis of biologically important compounds.


Keywords


Synthesis; Naphthol; Naphthofuran; Salicylaldehyde; Biological activity; 2-Hydroxy-1-naphthaldehyde

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How to cite


Abdelwahab, A.; Fekry, S. Eur. J. Chem. 2021, 12(3), 340-359. doi:10.5155/eurjchem.12.3.340-359.2126
Abdelwahab, A.; Fekry, S. Synthesis, reactions and applications of naphthofurans: A review. Eur. J. Chem. 2021, 12(3), 340-359. doi:10.5155/eurjchem.12.3.340-359.2126
Abdelwahab, A., & Fekry, S. (2021). Synthesis, reactions and applications of naphthofurans: A review. European Journal of Chemistry, 12(3), 340-359. doi:10.5155/eurjchem.12.3.340-359.2126
Abdelwahab, Ashraf, & Salma Ashraf Hassan Fekry. "Synthesis, reactions and applications of naphthofurans: A review." European Journal of Chemistry [Online], 12.3 (2021): 340-359. Web. 20 Oct. 2021
Abdelwahab, Ashraf, AND Fekry, Salma. "Synthesis, reactions and applications of naphthofurans: A review" European Journal of Chemistry [Online], Volume 12 Number 3 (30 September 2021)

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