European Journal of Chemistry 2021, 12(3), 323-328 | doi: https://doi.org/10.5155/eurjchem.12.3.323-328.2134 | Get rights and content

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Pharmaceutical organic salt: Disordered crystal structure of levofloxacin with γ-resorcylic acid


Syed Muddassir Ali Mashhadi (1,*) orcid , Muhammad Nawaz Tahir (2) orcid , David Apperley (3) orcid , Moazzam Hussain Bhatti (4) orcid , Muhammad Ashfaq (5) orcid , Uzma Yunus (6) orcid

(1) Department of Chemistry, University of Agriculture Faisalabad (Depalpur Okara Campus), Okara, 56130, Pakistan
(2) Department of Physics, University of Sargodha, Sargodha, 40100, Pakistan
(3) Department of Chemistry, Durham University, Stockton Road, Durham, DH1 3LE, United Kingdom
(4) Department of Chemistry, Allama Iqbal Open University, Islamabad, 44310, Pakistan
(5) Department of Physics, University of Sargodha, Sargodha, 40100, Pakistan
(6) Department of Chemistry, Allama Iqbal Open University, Islamabad, 44310, Pakistan
(*) Corresponding Author

Received: 06 Jul 2021 | Revised: 02 Aug 2021 | Accepted: 08 Aug 2021 | Published: 30 Sep 2021 | Issue Date: September 2021

Abstract


This study reports an organic salt prepared from an antibacterial drug, levofloxacin and antioxidant γ-resorcylic acid. A simple preparation method leads to a crystal with disordered structure. The idea is to prepare an organic salt comprising of pharmaceutically acceptable acidic and basic components. The salt is characterised by IR, solid state NMR, and single crystal XRD. Crystal data for C25H26N3O8F: triclinic, space group P-1 (no. 2), a = 7.0037(8) Å, b = 12.764(3) Å, c = 13.909(3) Å, α = 104.821(4)°, β = 92.039(4)°, γ = 95.334(4)°, = 1194.6(4) Å3, Z = 2, T = 296(2) K, μ(MoKα) = 0.113 mm-1, Dcalc = 1.433 g/cm3, 16879 reflections measured (5.048° ≤ 2Θ ≤ 54.186°), 5139 unique (Rint = 0.0663, Rsigma = 0.0975) which were used in all calculations. The final R1 was 0.1121 (I>2σ(I)) and wR2 was 0.2505 (all data). SC-XRD analysis shows that the crystal packing is stabilized by strong H-bonding of type N-H···O and comparatively weak interactions of type C-H···O, C-H···π and off-set π···π stacking.


Keywords


SC-XRD; SS-NM;R Organic salt; Levofloxacin; γ-Resorcylic acid; Disordered crystal structure

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DOI: 10.5155/eurjchem.12.3.323-328.2134

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How to cite


Mashhadi, S.; Tahir, M.; Apperley, D.; Bhatti, M.; Ashfaq, M.; Yunus, U. Eur. J. Chem. 2021, 12(3), 323-328. doi:10.5155/eurjchem.12.3.323-328.2134
Mashhadi, S.; Tahir, M.; Apperley, D.; Bhatti, M.; Ashfaq, M.; Yunus, U. Pharmaceutical organic salt: Disordered crystal structure of levofloxacin with γ-resorcylic acid. Eur. J. Chem. 2021, 12(3), 323-328. doi:10.5155/eurjchem.12.3.323-328.2134
Mashhadi, S., Tahir, M., Apperley, D., Bhatti, M., Ashfaq, M., & Yunus, U. (2021). Pharmaceutical organic salt: Disordered crystal structure of levofloxacin with γ-resorcylic acid. European Journal of Chemistry, 12(3), 323-328. doi:10.5155/eurjchem.12.3.323-328.2134
Mashhadi, Syed, Muhammad Nawaz Tahir, David Apperley, Moazzam Hussain Bhatti, Muhammad Ashfaq, & Uzma Yunus. "Pharmaceutical organic salt: Disordered crystal structure of levofloxacin with γ-resorcylic acid." European Journal of Chemistry [Online], 12.3 (2021): 323-328. Web. 19 Oct. 2021
Mashhadi, Syed, Tahir, Muhammad, Apperley, David, Bhatti, Moazzam, Ashfaq, Muhammad, AND Yunus, Uzma. "Pharmaceutical organic salt: Disordered crystal structure of levofloxacin with γ-resorcylic acid" European Journal of Chemistry [Online], Volume 12 Number 3 (30 September 2021)

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