European Journal of Chemistry 2021, 12(4), 482-487 | doi: https://doi.org/10.5155/eurjchem.12.4.482-487.2138 | Get rights and content

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Synthesis and in vitro drug release of primaquine phosphate loaded PLGA nanoparticles


Bharat Patel (1,*) orcid , Satyendra Kumar Tripathi (2) orcid , Sandhya Pathak (3) orcid , Sandeep Shukla (4) orcid , Archna Pandey (5) orcid

(1) Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India
(2) Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India
(3) Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India
(4) Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India
(5) Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India
(*) Corresponding Author

Received: 06 Jul 2021 | Revised: 27 Sep 2021 | Accepted: 27 Oct 2021 | Published: 31 Dec 2021 | Issue Date: December 2021

Abstract


Plasmodium falciparum is one of the most common resistant Plasmodium species responsible for high rates of morbidity and mortality in malaria patients. Clinical guidelines for the management of Plasmodium falciparum include the use of a dose of primaquine phosphate resulting intolerable side effects. Therefore, the aim of this work was to formulate primaquine phosphate-loaded PLGA nanoparticles by using a nanoprecipitation method in order to increase its bioavailability to minimize drug intake. This leads to reduced toxicity and better therapeutic efficacy of the drug. The synthesized nanoparticles were characterized by using dynamic light scattering (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transformed infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (XRD). TEM analysis revealed the presence of smooth spherical-shaped nanoparticles. The drug DLS analysis confirmed the presence of negatively charged nanoparticles with particle size in the range of 100-400 nm. The drug release study was performed to analyses different kinetic models like zero-order model, first-order model, Higuchi model, Hixson-Crowell model, and Korsmeyer-Peppas model.


Keywords


Drug release; Nanoparticles; Bioavailability; Antimalarial drugs; Plasmodium species; Dynamic light scattering

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DOI: 10.5155/eurjchem.12.4.482-487.2138

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Funding information


University Grand Commission, Dr. Harisingh Gour Vishwavidyalaya, Sagar 470003, India.

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How to cite


Patel, B.; Tripathi, S.; Pathak, S.; Shukla, S.; Pandey, A. Eur. J. Chem. 2021, 12(4), 482-487. doi:10.5155/eurjchem.12.4.482-487.2138
Patel, B.; Tripathi, S.; Pathak, S.; Shukla, S.; Pandey, A. Synthesis and in vitro drug release of primaquine phosphate loaded PLGA nanoparticles. Eur. J. Chem. 2021, 12(4), 482-487. doi:10.5155/eurjchem.12.4.482-487.2138
Patel, B., Tripathi, S., Pathak, S., Shukla, S., & Pandey, A. (2021). Synthesis and in vitro drug release of primaquine phosphate loaded PLGA nanoparticles. European Journal of Chemistry, 12(4), 482-487. doi:10.5155/eurjchem.12.4.482-487.2138
Patel, Bharat, Satyendra Kumar Tripathi, Sandhya Pathak, Sandeep Shukla, & Archna Pandey. "Synthesis and in vitro drug release of primaquine phosphate loaded PLGA nanoparticles." European Journal of Chemistry [Online], 12.4 (2021): 482-487. Web. 17 Jan. 2022
Patel, Bharat, Tripathi, Satyendra, Pathak, Sandhya, Shukla, Sandeep, AND Pandey, Archna. "Synthesis and in vitro drug release of primaquine phosphate loaded PLGA nanoparticles" European Journal of Chemistry [Online], Volume 12 Number 4 (31 December 2021)

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