European Journal of Chemistry

Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine

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Published: Sep 30, 2022
DOI: https://doi.org/10.5155/eurjchem.13.3.299-306.2280
Keywords:
Metal complexes, Thiosemicarbazone, Antioxidant activity, Tridentate Schiff base, Antimicrobial activity, Spectroscopic methods
Section
Research Article
Issue
Vol. 13 No. 3 (2022): September 2022
Dates
Received 2022-04-22
Accepted 2022-05-12
Published 2022-09-30
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Line Edwige Tsakeng Ngoudjou
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
https://orcid.org/0000-0001-6752-7913
Awawou Gbambie Paboudam
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
https://orcid.org/0000-0002-2194-0072
Adrien Pamen Yepseu
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
https://orcid.org/0000-0002-2773-1351
Maurice Kuate
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
https://orcid.org/0000-0003-1655-4326
Giscard Doungmo
Institute of Inorganic Chemistry, Christian-Albrechts University of Kiel, Max-Eyth-Strasse 2, 24118 Kiel, Germany
https://orcid.org/0000-0002-6332-8260
Peter Teke Ndifon
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
https://orcid.org/0000-0001-9331-9034

Abstract

Ni(II), Cu(II), and Zn(II) complexes of the tridentate heterocyclic ligand, 2-(phenyl(pyridin-2-yl)methylene)hydrazine-1-carbothioamide (HL) have been synthesized and characterized by various spectroscopic techniques and elemental analyses. Infrared spectroscopy shows that the ligand coordinates to the metal ions through the azomethine and pyridine nitrogen atoms as well as the sulfur atom of the thioamide group to form a tridentate chelate system. In vitro screening of metal complexes against four bacterial strains (Staphylococcus aureus (ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Methicillin resistant staphylococcus aureus (ATCC 33591), Shigella flexneri (NR 518)) and four fungal strains (Candida albicans (NR 29444), Candida albicans (NR 29445), Candida albicans (NR 29451), Candida krusei (HM 1122)) indicate that the Cu(II) complex showed good antibacterial activity on Methicillin resistant staphylococcus aureus (ATCC 33591) while the Zn(II) complex showed moderate activity against some of the bacterial and fungi strains. Antioxidant studies reveal that the complexes are more potent than the ligand to eliminate free radicals, with the Ni(II) complex showing the best free radical scavenger.


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Ngoudjou, L. E. T.; Paboudam, A. G.; Yepseu, A. P.; Kuate, M.; Doungmo, G.; Ndifon, P. T. Synthesis, Characterization, and Biological Activity of Cu(II), Ni(II), and Zn(II) Complexes of a Tridentate Heterocyclic Schiff Base Ligand Derived from Thiosemicarbazide and 2-Benzoylpyridine. Eur. J. Chem. 2022, 13, 299-306.

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