European Journal of Chemistry 2022, 13(3), 299-306 | doi: https://doi.org/10.5155/eurjchem.13.3.299-306.2280 | Get rights and content

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Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine


Line Edwige Tsakeng Ngoudjou (1) orcid , Awawou Gbambie Paboudam (2) orcid , Adrien Pamen Yepseu (3) orcid , Maurice Kuate (4) orcid , Giscard Doungmo (5) orcid , Peter Teke Ndifon (6,*) orcid

(1) Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
(2) Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
(3) Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
(4) Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
(5) Institute of Inorganic Chemistry, Christian-Albrechts University of Kiel, Max-Eyth-Strasse 2, 24118 Kiel, Germany
(6) Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé 1, P.O Box: 812 Yaoundé, Cameroon
(*) Corresponding Author

Received: 22 Apr 2022 | Revised: 07 Jun 2022 | Accepted: 16 Jun 2022 | Published: 30 Sep 2022 | Issue Date: September 2022

Abstract


Ni(II), Cu(II), and Zn(II) complexes of the tridentate heterocyclic ligand, 2-(phenyl(pyridin-2-yl)methylene)hydrazine-1-carbothioamide (HL) have been synthesized and characterized by various spectroscopic techniques and elemental analyses. Infrared spectroscopy shows that the ligand coordinates to the metal ions through the azomethine and pyridine nitrogen atoms as well as the sulfur atom of the thioamide group to form a tridentate chelate system. In vitro screening of metal complexes against four bacterial strains (Staphylococcus aureus (ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Methicillin resistant staphylococcus aureus (ATCC 33591), Shigella flexneri (NR 518)) and four fungal strains (Candida albicans (NR 29444), Candida albicans (NR 29445), Candida albicans (NR 29451), Candida krusei (HM 1122)) indicate that the Cu(II) complex showed good antibacterial activity on Methicillin resistant staphylococcus aureus (ATCC 33591) while the Zn(II) complex showed moderate activity against some of the bacterial and fungi strains. Antioxidant studies reveal that the complexes are more potent than the ligand to eliminate free radicals, with the Ni(II) complex showing the best free radical scavenger.


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Keywords


Metal complexes; Thiosemicarbazone; Antioxidant activity; Tridentate Schiff base; Antimicrobial activity; Spectroscopic methods

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DOI: 10.5155/eurjchem.13.3.299-306.2280

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Funding information


The “Fond Spéciale pour la Modernization de la Recherche Universitaire au Cameroun” (Decree n° 2009/121 of 8 April 2009), Cameroun.

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How to cite


Ngoudjou, L.; Paboudam, A.; Yepseu, A.; Kuate, M.; Doungmo, G.; Ndifon, P. Eur. J. Chem. 2022, 13(3), 299-306. doi:10.5155/eurjchem.13.3.299-306.2280
Ngoudjou, L.; Paboudam, A.; Yepseu, A.; Kuate, M.; Doungmo, G.; Ndifon, P. Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine. Eur. J. Chem. 2022, 13(3), 299-306. doi:10.5155/eurjchem.13.3.299-306.2280
Ngoudjou, L., Paboudam, A., Yepseu, A., Kuate, M., Doungmo, G., & Ndifon, P. (2022). Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine. European Journal of Chemistry, 13(3), 299-306. doi:10.5155/eurjchem.13.3.299-306.2280
Ngoudjou, Line, Awawou Gbambie Paboudam, Adrien Pamen Yepseu, Maurice Kuate, Giscard Doungmo, & Peter Teke Ndifon. "Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine." European Journal of Chemistry [Online], 13.3 (2022): 299-306. Web. 3 Dec. 2022
Ngoudjou, Line, Paboudam, Awawou, Yepseu, Adrien, Kuate, Maurice, Doungmo, Giscard, AND Ndifon, Peter. "Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine" European Journal of Chemistry [Online], Volume 13 Number 3 (30 September 2022)

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