European Journal of Chemistry

pH and time effectiveness on azithromycin drug: A spectrophotometric approach

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Published: Jun 30, 2024
DOI: https://doi.org/10.5155/eurjchem.15.2.120-127.2522
Keywords:
Reduction, Drug stability , Acidity effect, Azithromycin, Spectrophotometry, Potassium permanganate
Section
Research Article
Issue
Vol. 15 No. 2 (2024): June 2024
Dates
Received 2024-02-20
Accepted 2024-04-27
Published 2024-06-30
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Main Article Content

Adel Ahmed Saeed
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0000-0002-1154-2994
Mokhtar Salim Al-Salimi
Department of Chemistry, Yafea University College, University of Lahej, Yafea, 009673, Yemen
https://orcid.org/0000-0002-5162-9242
Amani Khalid Muthanna
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0005-2205-491X
Maysa Thabet Saleh
The Supreme Board of Drug and Medical Appliances, Aden, 009672, Yemen
https://orcid.org/0009-0006-6260-8478
Ahmed Hassan Ahmed
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0005-1497-5428
Fadhel Mahmoud Qasam
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0007-2438-5100
Hadeel Adnan Alwan
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0009-0810-9012
Ibrahim Mukhtar Alturky
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0001-1501-382X
Musab Muhammed Hamood
Department of Chemistry, Faculty of Science, University of Aden, Aden, 009672, Yemen
https://orcid.org/0009-0002-9719-1407

Abstract

The present study describes a straightforward method to assess the quality control and diagnostic characteristics of three different brands of film-coated azithromycin tablets. The method is based on the reduction of potassium permanganate in a slightly alkaline solution using azithromycin. The effects of acidity and time were investigated to evaluate the reliability of the method. A spectroscopic technique was used to determine the concentration of azithromycin in a sample by measuring the decrease in potassium permanganate absorbance at a specific wavelength of 547 nm. Azithromycin causes decolorization of potassium permanganate with reduction. The method allowed the determination of azithromycin concentrations ranging from 3-15 μg/mL in the final solution. The usual components present in the azithromycin tablets were observed not to interfere with the method. The results obtained for the determination of azithromycin in tablets were in good agreement with the allowed limit.


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Saeed, A. A.; Al-Salimi, M. S.; Muthanna, A. K.; Saleh, M. T.; Ahmed, A. H.; Qasam, F. M.; Alwan, H. A.; Alturky, I. M.; Hamood, M. M. PH and Time Effectiveness on Azithromycin Drug: A Spectrophotometric Approach. Eur. J. Chem. 2024, 15, 120-127.

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