Synthesis and in vitro evaluation of tetrazole containing 1,5-benzothiazepines as new anticancer, antitubercular, antibacterial, and antifungal agents

Ashok Kumar Suman; Anu Anu; Bhawani Singh

doi:10.5155/eurjchem.15.3.245-253.2569

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Published: Sep 30, 2024

DOI: https://doi.org/10.5155/eurjchem.15.3.245-253.2569

Keywords:

Tetrazoles, Antifungal activity, Anticancer activity, Antibacterial activity, 1,5-Benzothiazepines, Antitubercular activity

Section

Research Article

Issue

Vol. 15 No. 3 (2024): September 2024

Dates

Received 2024-06-01
Accepted 2024-08-08
Published 2024-09-30

Ashok Kumar Suman

Department of Pure and Applied Chemistry, Faculty of Science, University of Kota, Kota, 324005, India

https://orcid.org/0000-0002-6049-7157

Anu Anu

Department of Pure and Applied Chemistry, Faculty of Science, University of Kota, Kota, 324005, India

https://orcid.org/0009-0009-4473-9601

Bhawani Singh

Department of Pure and Applied Chemistry, Faculty of Science, University of Kota, Kota, 324005, India

https://orcid.org/0000-0002-8754-3483

Abstract

Heterocyclic scaffolds have attracted great attention of organic chemists and medicinal chemists, also because of their wide range of synthetic applicability and broad spectrum of biological profile. Therefore, in the present research work, a series of tetrazole containing 1,5-benzothiazepines have been synthesized for evaluation of their biological activities to determine the potential therapeutic profile of these compounds across various medicinal domains. Of the synthesized compounds, five compounds (6f, 8e, 8f, 8g, and 8h) have been screened for anticancer, antitubercular, antibacterial, and antifungal activities. After evaluation of these biological activities, it was found that these compounds possess very limited anticancer activity, moderate antibacterial and antifungal activity, and very strong antitubercular activity, which indicate their great pharmacological applications as subjects for future investigations of novel therapeutic agents for the treatment of tuberculosis.

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Suman, A. K.; Anu, A.; Singh, B. Synthesis and in Vitro Evaluation of Tetrazole Containing 1,5-Benzothiazepines As New Anticancer, Antitubercular, Antibacterial, and Antifungal Agents. Eur. J. Chem. 2024, 15, 245-253.

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Supporting Agencies

Department of Pure and Applied Chemistry, Faculty of Science, University of Kota, Kota, 324005, India, Materials Research Centre (MRC), Malviya National Institute of Technology (MNIT), Jaipur (Rajasthan), India; the Central Instrumentation Laboratory (CIL), Guru Jambheshwar University of Science & Technology, Hisar (Haryana) and AccuPhyChem Analytics, Jaipur (Rajasthan), India, Biomitra Life Sciences Pvt. Ltd., Jaipur (Rajasthan), India.

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