Redox behavior of aliphatic hydroxamic acid and its iron(III) complexes

Ibrahima Sory Sow; Marie Vandeput; Michel Gelbcke; François Dufrasne

doi:10.5155/eurjchem.15.4.307-312.2586

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Published: Dec 31, 2024

DOI: https://doi.org/10.5155/eurjchem.15.4.307-312.2586

Keywords:

pH, Iron complex , Concentration, Redox potential, Hydroxamic acid, Cyclic voltammetry

Section

Research Article

Issue

Vol. 15 No. 4 (2024): December 2024

Dates

Received 2024-08-19
Accepted 2024-11-08
Published 2024-12-31

Ibrahima Sory Sow

Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université libre de Bruxelles, 1050 Brussels, Belgium

https://orcid.org/0000-0003-4038-7927

Marie Vandeput

Pharmacognosy, Bioanalysis and Drug Discovery Research Unit (RD3-PBM), Faculty of Pharmacy, Université libre de Bruxelles, 1050 Brussels, Belgium

https://orcid.org/0000-0001-6982-3302

Michel Gelbcke

Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université libre de Bruxelles, 1050 Brussels, Belgium

https://orcid.org/0009-0008-7202-6214

François Dufrasne

Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université libre de Bruxelles, 1050 Brussels, Belgium

https://orcid.org/0000-0001-6288-7936

Abstract

N-Hydroxydodecanamide (HA12) and its trihydroxamato-iron(III) complex (HA12Fe3) have been synthesized and characterized by various methods including structural determination by single crystal X-ray diffraction and cyclic voltammetry (CV). In order to complete our previous CV study on HA12 and its complexes, our aim was to investigate the variation in redox potential upon changes in concentration and pH. The redox couples previously observed with HA12 and HA12Fe3 at 100 µM shifts towards less positive values when the concentration or pH of the solution increases. These results indicate that oxidation is easier when concentrations are higher and in basic media. The slopes of -0.06 V/pH (in agreement with the theoretical data) and -0.077 V/pH (slightly higher than the theoretical slope) were observed for HA12 and HA12Fe3, respectively. This observation would explain the slower oxidation of HA12Fe3 than HA12.

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(1)

Sow, I. S.; Vandeput, M.; Gelbcke, M.; Dufrasne, F. Redox Behavior of Aliphatic Hydroxamic Acid and Its iron(III) Complexes. Eur. J. Chem. 2024, 15, 307-312.

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Supporting Agencies

Université libre de Bruxelles, 1050 Brussels, Belgium, Minister of Higher Education and Scientific Research of Guinea, Guinea

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