European Journal of Chemistry

Substituted Quinolinones. Part 16. Preparation and reactions of 3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid



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Mohamed Abass
Elhossain Ali Mohamed
Mostafa Mohamed Ismail
Aisha Saleh Mayas

Abstract

Preparation of quinolinyl-3-oxopropanoic acid was accomplished by hydrolysis of pyranoquinolinedione, in aqueous alkaline medium. The chemical behavior of this β-keto acid towards nitrosation, coupling with a diazonium salt, esterification, condensation with 2,2-diethoxyethanamine, hydrazinolysis, Knoevenagel condensation with isatine, salicylaldehyde, 3-formylquinolones, and 3-formylchromone, was investigated. Also many of the products of these reactions were obtained using either pyranoquinolinedione 1 or β-keto acid 2, under the same conditions.

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Abass, M.; Mohamed, E. A.; Ismail, M. M.; Mayas, A. S. Substituted Quinolinones. Part 16. Preparation and Reactions of 3-(4-Hydroxy-1-Methyl-2-Oxo-1,2-Dihydroquinolin-3-Yl)-3-Oxopropanoic Acid. Eur. J. Chem. 2011, 2, 378-387.

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