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Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines


Mamta Rani (1,*) , Mohamad Yusuf (2)

(1) Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
(2) Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
(*) Corresponding Author

Received: 26 May 2011 | Revised: 28 Jul 2011 | Accepted: 02 Aug 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract


Bis-pyrazoline darivatives (2a-e) built around the alkyl chains of varying length were synthesized in good yield by refluxing bis-chalcones (1a-e) with phenyl hydrazine in CH3COOH and ethanol. The structures of these compounds were elucidated by IR, 1H NMR, 13C NMR, Mass (ESI) spectrometries and their purities were confirmed by elemental analyses. The antibacterial activity of these compounds were evaluated by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration of compounds were determined. The compounds 1,4-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole] butane (2a) and 1,10-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole]decane (2e) are better antibacterial agent as compared to Tetracycline and Gentamicin.

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Editor-in-Chief
European Journal of Chemistry

Keywords


Gentamicin; Tetracycline; Bis-chalcones; Bis-pyrazoline; Phenyl hydrazine; Antibacterial activity

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DOI: 10.5155/eurjchem.3.1.21-25.472

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Funding information


Rajiv Gandhi National fellowship, University Grants Commission, New Delhi, India

Citations

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[1]. Kalpesh V. Vilapara, Sagar P. Gami, Shobhna A. Gadara, Yogesh T. Naliapara
Copper Catalyzed Chan-Lam Coupling Reaction of Pyrazoles at Ambient Temperature and their Antimicrobial Evaluation
Asian Journal of Chemistry  31(12), 2981, 2019
DOI: 10.14233/ajchem.2019.22370
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[2]. Saba Farooq, Zainab Ngaini
One-Pot and Two-Pot Synthesis of Chalcone Based Mono and Bis-Pyrazolines
Tetrahedron Letters  61(4), 151416, 2020
DOI: 10.1016/j.tetlet.2019.151416
/


[3]. Mamta Rani, Mohamad Yusuf
Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives
European Journal of Chemistry  3(4), 406, 2012
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[4]. Arindam Sarkar, Soumyadipta Rakshit, Subhash Chandra Bhattacharya
Interpreting the effect of confined cyclodextrin media on the FRET efficacy between Naproxen and a bio-active 3-pyrazolyl-2-pyrazoline derivative on the light of spectroscopic investigation appended by TD-DFT simulations and molecular docking analysis
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[5]. Soumya Sundar Mati, Sunandan Sarkar, Soumyadipta Rakshit, Arindam Sarkar, Subhash Chandra Bhattacharya
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[6]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
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How to cite


Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472
Rani, M.; Yusuf, M. Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. Eur. J. Chem. 2012, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472
Rani, M., & Yusuf, M. (2012). Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. European Journal of Chemistry, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472
Rani, Mamta, & Mohamad Yusuf. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines." European Journal of Chemistry [Online], 3.1 (2012): 21-25. Web. 24 Sep. 2023
Rani, Mamta, AND Yusuf, Mohamad. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

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