Synthesis and in-vitro antibacterial activity of some alkoxy based  N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines

Mamta Rani; Mohamad Yusuf

doi:10.5155/eurjchem.3.1.21-25.472

European Journal of Chemistry 2012, 3(1), 21-25 | doi: https://doi.org/10.5155/eurjchem.3.1.21-25.472 | Get rights and content

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Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines

Mamta Rani ^(1,*)

, Mohamad Yusuf ⁽²⁾

⁽¹⁾ Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
⁽²⁾ Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
^(*) Corresponding Author

Received: 26 May 2011 | Revised: 28 Jul 2011 | Accepted: 02 Aug 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract

Bis-pyrazoline darivatives (2a-e) built around the alkyl chains of varying length were synthesized in good yield by refluxing bis-chalcones (1a-e) with phenyl hydrazine in CH₃COOH and ethanol. The structures of these compounds were elucidated by IR, ¹H NMR, ¹³C NMR, Mass (ESI) spectrometries and their purities were confirmed by elemental analyses. The antibacterial activity of these compounds were evaluated by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration of compounds were determined. The compounds 1,4-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole] butane (2a) and 1,10-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole]decane (2e) are better antibacterial agent as compared to Tetracycline and Gentamicin.

3_1_21_25_800

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Editor-in-Chief
European Journal of Chemistry

Keywords

Gentamicin; Tetracycline; Bis-chalcones; Bis-pyrazoline; Phenyl hydrazine; Antibacterial activity

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DOI: 10.5155/eurjchem.3.1.21-25.472

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Funding information

Rajiv Gandhi National fellowship, University Grants Commission, New Delhi, India

Citations

[1]. Kalpesh V. Vilapara, Sagar P. Gami, Shobhna A. Gadara, Yogesh T. Naliapara
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Asian Journal of Chemistry 31(12), 2981, 2019
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[2]. Saba Farooq, Zainab Ngaini
One-Pot and Two-Pot Synthesis of Chalcone Based Mono and Bis-Pyrazolines
Tetrahedron Letters 61(4), 151416, 2020
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[3]. Mamta Rani, Mohamad Yusuf
Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives
European Journal of Chemistry 3(4), 406, 2012
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[4]. Arindam Sarkar, Soumyadipta Rakshit, Subhash Chandra Bhattacharya
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How to cite

Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472

Rani, M.; Yusuf, M. Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. Eur. J. Chem. 2012, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472

Rani, M., & Yusuf, M. (2012). Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. European Journal of Chemistry, 3(1), 21-25. doi:10.5155/eurjchem.3.1.21-25.472

Rani, Mamta, & Mohamad Yusuf. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines." European Journal of Chemistry [Online], 3.1 (2012): 21-25. Web. 24 Sep. 2023

Rani, Mamta, AND Yusuf, Mohamad. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

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