European Journal of Chemistry

Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity



Main Article Content

Sohail Anjum Shahzad
Muhammad Yar
Zulfiqar Ali Khan
Islam Ullah Khan
Syed Ali Raza Naqvi
Nasir Mahmood
Khalid Mohammed Khan

Abstract

An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM.

3_2_143_146_800


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Shahzad, S. A.; Yar, M.; Khan, Z. A.; Khan, I. U.; Naqvi, S. A. R.; Mahmood, N.; Khan, K. M. Microwave-Assisted Solvent Free Efficient Synthesis of 1,3,4-Oxadiazole-2(3H)-Thiones and Their Potent in Vitro Urease Inhibition Activity. Eur. J. Chem. 2012, 3, 143-146.

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