European Journal of Chemistry

Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones

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Published: Sep 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.3.273-278.605
Keywords:
Triazoles, Pyrazoles, Tetrazoles, Enaminones, Ditetrazoles, Furopyrimidines
Section
Research Article
Issue
Vol. 3 No. 3 (2012): September 2012
Dates
Received 2012-02-29
Accepted 2012-04-15
Published 2012-09-30


Main Article Content

Mohamed Abdel Megid Abdel-Hamid
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
Azza Mohamed Elkazak
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
Magdy Hamed Sead
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
Osama Farouk Mohamed
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

Abstract

Some novel pyrazolylfuropyrimidinethiones were synthesized from cyclocondensation of 4-hydrazino-5,6-diphenylfuro [2,3-d] pyrimidine-2(1H)-thione (3) with different enaminones and 1,3-dicarbonyl compounds. Whereas the furotriazolo-pyrimidinethiones were synthesized from reaction of compound 3 with benzoyl chloride, p-chlorobenzaldehyde and carbon disulphide. Furthermore, furotetrazolo-pyrimidinethione and ditetrazolofuro pyrimidine were synthesized.

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How to Cite
(1)
Abdel-Hamid, M. A. M.; Elkazak, A. M.; Sead, M. H.; Mohamed, O. F. Synthesis of Some New Pyrazolylfuropyrimidinethiones and Triazolofuropyrimidinethiones. Eur. J. Chem. 2012, 3, 273-278.

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References

[1]. Pang, W.; Zhu, S.; Xin, Y.; Jiang, H.; Zhu, Z. Tetrahedron 2010, 66, 1261-1266.
http://dx.doi.org/10.1016/j.tet.2009.12.015

[2]. Abdel-Megid, M.; Elkazak, A. M.; Seada, M.; Farouk, O. S. J. Appl. Sci. Res. 2010, 6 (12), 2133-2138.

[3]. Maedo, Y.; Nakano, M.; Sato, H.; Migazak, Y.; Schweiker, S. L.; Smith, J. L.; Truesdale, A. T. Bioorg. Med. Chem. Lett. 2004, 14, 3907-3911.
http://dx.doi.org/10.1016/j.bmcl.2004.05.064

[4]. Bhuiyan, M. M. H.; Rahman, K. M. M.; Hossain, M. K.; Rahim, M. A.; Hossain, M. I. Croat. Chem Acta. 2005, 78, 633-636.

[5]. Gangjee, A.; Zeng, Y.; McGuire, J. J.; Kisliuk, R. L. J. Med. Chem. 2005, 48, 5329-5336.
http://dx.doi.org/10.1021/jm058213s
PMid:16078850 PMCid:2538949

[6]. Dave, C. G.; Shah, R. D. Molecules 2002, 7, 554-565.
http://dx.doi.org/10.3390/70700554

[7]. Gangjee, A.; Zeng, Y.; Ihnat, M.; Warnke, L. A.; Green, D. W.; Kisliuk, R. L.; Lin, F. T. Bioorg. Med. Chem. 2005, 13, 5475-5491.
http://dx.doi.org/10.1016/j.bmc.2005.04.087

[8]. Janeba, Z.; Balzarini, J.; Andrei, G.; Snoeck, R.; De Clercq, E.; Robins M. J. J. Med. Chem. 2005, 48, 4690-4696.
http://dx.doi.org/10.1021/jm050291s
PMid:16000005

[9]. Robins, M. J.; Miranda, K.; Rajwanshi, V. K.; Peterson, M. A.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. J. J. Med. Chem. 2006, 49, 391-398.
http://dx.doi.org/10.1021/jm050867d
PMid:16392824

[10]. Abdel-Megid, M. J. Synth. Commun. 2007, 37, 3211-3218.
http://dx.doi.org/10.1080/00397910701547847

[11]. Abdel-Megid, M. Pharmazie 2000, 55, 263-268.
PMid:10798238

[12]. Abdel-Megid, M.; Abbas, M.; Hassan, M. J. Heterocycl. Chem. 2007, 44, 315-322.
http://dx.doi.org/10.1002/jhet.5570440206

[13]. Ali, T. E. Eur. J. Med. Chem. 2009, 44, 4385-4392.
http://dx.doi.org/10.1016/j.ejmech.2009.06.022
PMid:19615792

[14]. Behalo, M. S. Phosphorus Sulfur 2009, 184 (14), 206-219.

[15]. Abu-Zied, K. H. Phosphorus Sulfur 2007, 182 (28), 447-474.
http://dx.doi.org/10.1080/10426500600977304

[16]. Hussein, A. H. M.; El-Gaby, M. S.; Abu-Shanab, F.; Abdel-Raheim, A. M. Org. Commun. 2009, 2(3), 66-71.

[17]. Gewald, K. Chem. Ber. 1966, 99, 1002-1007.
http://dx.doi.org/10.1002/cber.19660990340

[18]. Korbukh, I. A.; Bulychev, Y. N.; Preobrazhenskaya, M. N. Chem. Heterocyc. Compd. 1979, 15 (12), 1361-1366.
http://dx.doi.org/10.1007/BF00514744

[19]. Kmetic, M.; Stanovnik, B. J. Heterocycl. Chem. 1995, 32, 1563-1565.
http://dx.doi.org/10.1002/jhet.5570320525

[20]. Abdel-Megid, M. Chem. Heterocycl. Compd. 2010, 3, 405-414.

[21]. Abdel-Megid, M. Internat. J. Chem. 2006, 16 (3), 149-15

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