European Journal of Chemistry

Synthesis and characterization of 1'-benzyl-1,4'-dimethyl-2'propyl-1H,1'H-2,6'-dibenzimidazole derivatives and their antibacterial activity studies



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Doddarasinakere Kempaiah Ravishankara
Paduvalahippe Gowdegowda Chandrashekara

Abstract

A series of 1'-benzyl-1,4'-dimethyl-2'propyl-1H,1'H-2,6'-dibenzimidazole derivatives have been synthesized and characterized by  FT-IR, 1H NMR, MS and elemental analyses. Furthermore, these compounds were screened for anti-bacterial study. Ampicillin is the drug used as a standard, for comparision with all the synthesized molecules.

3_3_363_366_800


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Ravishankara, D. K.; Chandrashekara, P. G. Synthesis and Characterization of 1’-Benzyl-1,4’-Dimethyl-2’propyl-1H,1’H-2,6’-Dibenzimidazole Derivatives and Their Antibacterial Activity Studies. Eur. J. Chem. 2012, 3, 363-366.

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References

[1]. Goker, H.; Kus, C.; Abbasoglu, U. Arch Pharm (Weinheim) 1995, 328, 425-430.
http://dx.doi.org/10.1002/ardp.19953280506

[2]. Garuti, L.; Roberti, M.; Gentilomi, G. Il Farmaco 2000, 55, 35-39.
http://dx.doi.org/10.1016/S0014-827X(99)00117-2

[3]. Tonelli, M.; Simone, M.; Tasso, B.; Novelli, F.; Boido, V.; Sparatore, F.; Paglietti, G.; Pricl, S.; Giliberti, G.; Blois, S.; Ibba, C.; Sanna, G.; Loddo, R.; La Colla, P. Bioorg. Med. Chem. 2010, 18, 2937-2953.
http://dx.doi.org/10.1016/j.bmc.2010.02.037

[4]. Tonelli, M.; Boido, V.; La Colla, P.; Loddo, R.; Posocco, P.; Paneni, M. S.; Fermeglia, M.; Pricl, S. Bioorg. Med. Chem. 2010, 18, 2304-2316.
http://dx.doi.org/10.1016/j.bmc.2010.01.058

[5]. Keurulainen, L.; Salin, O.; Siiskonen, A.; Kern, J. M.; Alvesalo, J.; Kiuru, P.; Maass, M.; Yli-Kauhaluoma, J.; Vuorela, P. J. Med. Chem. 2010, 53, 7664-7674.
http://dx.doi.org/10.1021/jm1008083
PMid:20932010

[6]. Lyakhova, E. A.; Gusyeva, Y. A.; Nekhoroshkova, J. V.; Shafran, L. M.; Lyakhov, S. A. Eur. J. Med. Chem. 2009, 44, 3305-3312.
http://dx.doi.org/10.1016/j.ejmech.2009.03.004
PMid:19349097

[7]. Navarrete-Vazquez, G.; Hidalgo-Figueroa, S.; Torres-Piedra, M.; Vergara-Galicia, J.; Rivera-Leyva, J. C.; Estrada-Soto, S.; Leon-Rivera, I.; Aguilar-Guardarrama, B.; Rios-Gomez, Y.; Villalobos-Molina, R.; Ibarra-Barajas, M. Bioorg. Med. Chem. 2010, 18, 3985-3991.
http://dx.doi.org/10.1016/j.bmc.2010.04.027

[8]. Rohini, R.; Shanker, K.; Reddy, P. M.; Ho, Y. P.; Ravinder, V. Eur. J. Med. Chem. 2009, 44, 3330-3339.
http://dx.doi.org/10.1016/j.ejmech.2009.03.022
PMid:19371978

[9]. Sharma, D.; Narasimhan, B.; Kumar, P.; Jalbout, A. Eur. J. Med. Chem. 2009, 44, 1119-1127.
http://dx.doi.org/10.1016/j.ejmech.2008.06.009
PMid:18657885

[10]. Kus, C.; Ayhan-Kilcigil, G.; Ozbey, S.; Kaynak, F. B.; Kaya, M.; Coban, T.; Can-Eke, B. Bioorg. Med. Chem. 2008, 16, 4294-4303.
http://dx.doi.org/10.1016/j.bmc.2008.02.077

[11]. Savall, B. M.; Edwards, J. P.; Venable, J. D.; Buzard, D. J.; Thurmond, R.; Hack, M.; McGovern, P. Bioorg. Med. Chem. Lett. 2010, 20, 3367-3371.
http://dx.doi.org/10.1016/j.bmcl.2010.04.017

[12]. Kim, J. S.; Gatto, B.; Yu, C.; Liu, A.; Liu, L. F.; LaVoie, E. J. J. Med. Chem. 1996, 39, 992-998.
http://dx.doi.org/10.1021/jm950412w
PMid:8632422

[13]. White, A. W.; Curtin, N. J.; Eastman, B. W.; Golding, B. T.; Hostomsky, Z.; Kyle, S.; Li, J.; Maegley, K. A.; Skalitzky, D. J.; Webber, S. E.; Yu, X. H.; Griffin, R. J. Bioorg. Med. Chem. Lett. 2004, 14, 2433-2437.
http://dx.doi.org/10.1016/j.bmcl.2004.03.017

[14]. White, A. W.; Almassy, R.; Calvert, A. H.; Curtin, N. J.; Griffin, R. J.; Hostomsky, Z.; Maegley, K.; Newell, D. R.; Srinivasan, S.; Golding, B. T. J. Med. Chem. 2000, 43, 4084-4097.
http://dx.doi.org/10.1021/jm000950v
PMid:11063605

[15]. Neff, D. K.; Lee-Dutra, A.; Blevitt, J. M.; Axe, F. U.; Hack, M. D.; Buma, J. C.; Rynberg, R.; Brunmark, A.; Karlsson, L.; Breitenbucher, J. G. Bioorg. Med. Chem. Lett. 2007, 17, 6467-6471.
http://dx.doi.org/10.1016/j.bmcl.2007.09.098

[16]. Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Pandit, C. R.; Karlsson, L.; Breitenbucher, J. G. J. Med. Chem. 2005, 48, 1873-1885.
http://dx.doi.org/10.1021/jm0495935
PMid:15771432

[17]. Vock, C. A.; Ang, W. H.; Scolaro, C.; Phillips, A. D.; Lagopoulos, L.; Juillerat-Jeanneret, L.; Sava, G.; Scopelliti, R.; Dyson, P. J. J. Med. Chem. 2007, 50, 2166-2175.
http://dx.doi.org/10.1021/jm070039f
PMid:17419606

[18]. McBride, C. M.; Renhowe, P. A.; Heise, C.; Jansen, J. M.; Lapointe, G.; Ma, S.; Pineda, R.; Vora, J.; Wiesmann, M.; Shafer, C. M. Bioorg. Med. Chem. Lett. 2006, 16, 3595-3599.
http://dx.doi.org/10.1016/j.bmcl.2006.03.069

[19]. Hasegawa, M.; Nishigaki, N.; Washio, Y.; Kano, K.; Harris, P. A.; Sato, H.; Mori, I.; West, R. I.; Shibahara, M.; Toyoda, H.; Wang, L.; Nolte, R. T.; Veal, J. M.; Cheung, M. J. Med. Chem. 2007, 50, 4453-4470.
http://dx.doi.org/10.1021/jm0611051
PMid:17676829

[20]. Hubbard, R. D.; Bamaung, N. Y.; Fidanze, S. D.; Erickson, S. A.; Palazzo, F.; Wilsbacher, J. L.; Zhang, Q.; Tucker, L. A.; Hu, X.; Kovar, P.; Osterling, D. J.; Johnson, E. F.; Bouska, J.; Wang, J.; Davidsen, S. K.; Bell, R. L.; Sheppard, G. S. Bioorg. Med. Chem. Lett. 2009, 19, 1718-1721.
http://dx.doi.org/10.1016/j.bmcl.2009.01.086

[21]. Reddy, K. S.; Srinivasan, N.; Reddy, C. R.; Kolla, N.; Anjaneyulu, Y.; Venkatraman, S.; Bhattacharya, A.; Mathad, V. T. Org. Process Res. Dev. 2007, 11, 81-85.
http://dx.doi.org/10.1021/op060200g

[22]. Kumar, R.; Nair, R. R.; Dhiman, S. S.; Sharma, J.; Prakash, O. Eur. J. Med. Chem. 2009, 44(5), 2260-2264.
http://dx.doi.org/10.1016/j.ejmech.2008.06.004
PMid:18657340

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Sri Mahadeshwara Government First Grade College, Kollegal, India
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