European Journal of Chemistry

Anticancer activity studies of some cyclic benzimidazole derivatives

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Published: Sep 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.3.356-358.621
Keywords:
PC3 cells, Hela cells, Cytotoxicity, Anti-cancer activity, Benzimidazole derivatives, 4-Amino-2-(3, 4, 5-trimethoxyphenyl)benzo[4, 5]imidazo[1, 2-a]pyrimidine-3-carbonitrile
Section
Research Article
Issue
Vol. 3 No. 3 (2012): September 2012
Dates
Received 2012-04-23
Accepted 2012-06-17
Published 2012-09-30


Main Article Content

Ali El-Shekeil
Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
Abeer Omer Obeid
Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
Sama Al-Aghbari
Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen

Abstract

New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.

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El-Shekeil, A.; Obeid, A. O.; Al-Aghbari, S. Anticancer Activity Studies of Some Cyclic Benzimidazole Derivatives. Eur. J. Chem. 2012, 3, 356-358.

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