European Journal of Chemistry

Application of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) in the solvent free synthesis of (E)-arylidene-1,3-dihydroindole-2-ones

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Parisa Gholamzadeh
Ghodsi Mohammadi Ziarani
Alireza Badiei
Zohreh Bahrami


An efficient and green condensation reaction is developed for the synthesis of (E)-arylidene-1,3-dihydroindole-2-ones; (1), using heterogeneous nanoporous acid catalyst of SBA-Pr-SO3H with pore size, 6 nm in solvent free condition. Arylidene-1,3-dihydroindole-2-ones have many pharmaceutical properties such as Tyrosin kinase inhibiton. This method has the advantages of short reaction time, isolation ease of the products, excellent yields and recyclable catalyst.


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Gholamzadeh, P.; Ziarani, G. M.; Badiei, A.; Bahrami, Z. Application of Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) in the Solvent Free Synthesis of (E)-Arylidene-1,3-Dihydroindole-2-Ones. Eur. J. Chem. 2012, 3, 279-282.

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Supporting Agencies

Research Council of Alzahra University and the University of Tehran, Iran

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