European Journal of Chemistry 2010, 1(4), 322-324 | doi: https://doi.org/10.5155/eurjchem.1.4.322-324.65 | Get rights and content

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Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives


Sattar Ebrahimi (1,*)

(1) Department of Chemistry, Islamic Azad University, Malayer Branch, IR-65718-117, Iran
(*) Corresponding Author

Received: 16 Apr 2010 | Revised: 13 Aug 2010 | Accepted: 26 Sep 2010 | Published: 22 Dec 2010 | Issue Date: December 2010

Abstract


New 1,2,4-triazoles (4a-c), 1,3,4-thiadiazoles (5a-c) and 1,3,4-oxadiazoles (6a-c) containing isomeric pyridyl and cyclohexyl were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides (3a-c) in alkaline media, acid and neutral condition respectively. The chemical structures of newly synthesized compounds were established with help of FT-IR, 1H-NMR and mass spectral data.

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Keywords


1,2,4-Triazole; 1,3,4-Thiadiazole; 1,3,4-Oxadiazole; Thiosemicarbazide

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DOI: 10.5155/eurjchem.1.4.322-324.65

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Citations

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[1]. Noor M. Nasir, Tahseen A. Alsalim, Amr Ahmed El-Arabey, Mohnad Abdalla
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DOI: 10.1080/07391102.2022.2060306
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[2]. Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri
Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade
Molecules  27(9), 2709, 2022
DOI: 10.3390/molecules27092709
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[3]. Hossein Pasha Ebrahimi, Jabbar S. Hadi, Tahseen A. Alsalim, Thaer S. Ghali, Zeinab Bolandnazar
A novel series of thiosemicarbazone drugs: From synthesis to structure
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  137, 1067, 2015
DOI: 10.1016/j.saa.2014.08.146
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[4]. Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Mohamed M. Abdulla, Hoong-Kun Fun
Synthesis and antitumor activity of 4-cyclohexyl/aryl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
Medicinal Chemistry Research  24(4), 1558, 2015
DOI: 10.1007/s00044-014-1216-5
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[5]. Qiaoling Liu, Huizhi Du, Xiaoze Ren, Wei Bian, Li Fan, Shaomin Shuang, Chuan Dong, Qin Hu, Martin M. F. Choi
Design of Ratiometric Emission Probe with Visible Light Excitation for Determination of Ca2+ in Living Cells
Analytical Chemistry  86(16), 8025, 2014
DOI: 10.1021/ac5022002
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How to cite


Ebrahimi, S. Eur. J. Chem. 2010, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, S. Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives. Eur. J. Chem. 2010, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, S. (2010). Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives. European Journal of Chemistry, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, Sattar. "Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives." European Journal of Chemistry [Online], 1.4 (2010): 322-324. Web. 3 Dec. 2022
Ebrahimi, Sattar. "Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives" European Journal of Chemistry [Online], Volume 1 Number 4 (22 December 2010)

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