European Journal of Chemistry

Synthesis of bis(indolyl)methanes using molten N-butylpyridinium bromide

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Published: Dec 31, 2012
DOI: https://doi.org/10.5155/eurjchem.3.4.475-479.709
Keywords:
Molten salt, Designer solvent, Aromatic aldehydes, Bis(indolyl)methanes, Condensation reaction, Electrophilic substitution reaction
Section
Research Article
Issue
Vol. 3 No. 4 (2012): December 2012
Dates
Received 2012-11-16
Accepted 2012-11-29
Published 2012-12-31


Main Article Content

Gaurav Gupta
School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, India
Ganesh Chaudhari
Department of Chemistry, Moolji Jaitha College, Jalgaon, 425001, India
Preeti Tomar
Department of Applied Chemistry, Jaywant Shikshan Prasarak Mandal’s Rajashi Shahu College of Engineering, Pune, 411027, India
Yogesh Gaikwad
Anacon Laboratories, Nagpur, 440010, India
Rameez Azad
Anacon Laboratories, Nagpur, 440010, India
Girish Pandya
Anacon Laboratories, Nagpur, 440010, India
Govinda Waghulde
Department of Chemistry, Dadasaheb Devidas Namdeo Bhole, College, Bhusawal, 425201, India
Kesharsingh Patil
School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, India

Abstract

A simple and rapid protocol has been developed for the synthesis of bis(indolyl)methane compounds in excellent yields using molten N-butyl-pyridinium bromide as a solvent and a working catalyst for the reaction. Synthesis of bis(indolyl)methane compounds were accomplished at moderate experimental conditions of temperature and ambient pressure, also involving an electrophilic substitution reaction of indoles with several aromatic aldehydes. The derivatives were confirmed with mass and other usual spectroscopic techniques. A discussion on plausible mechanism for the reaction is also presented.

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Gupta, G.; Chaudhari, G.; Tomar, P.; Gaikwad, Y.; Azad, R.; Pandya, G.; Waghulde, G.; Patil, K. Synthesis of bis(indolyl)methanes Using Molten N-Butylpyridinium Bromide. Eur. J. Chem. 2012, 3, 475-479.

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