European Journal of Chemistry

Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide

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Published: Mar 31, 2013
DOI: https://doi.org/10.5155/eurjchem.4.1.44-48.717
Keywords:
Sulfamides, Kinetic study, Benzylsulfamide, Model-free method, Thermolysis reaction, Isoconversional method
Section
Research Article
Issue
Vol. 4 No. 1 (2013): March 2013
Dates
Received 2012-12-17
Accepted 2013-01-05
Published 2013-03-31


Main Article Content

Luciana Gavernet
Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
Maria Luisa Villalba
Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
Luis Bruno Blanch
Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
Ileana Daniela Lick
Department of Chemistry, Faculty of Exact Sciences, National University of La Plata, CINDECA (CCT-La Plata-CONICET-UNLP), La Plata, B1900BJW, Argentina

Abstract

In this investigation, a kinetic study of the thermolysis of N-(benzyl)-N´-(tert-butoxycarbonyl) sulfamide to yield benzylsulfamide in an efficient manner was performed. The thermolysis reaction was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 10 oC/min. The activation energy value was obtained from the Kissinger-Akahira-Sunose isoconversional method and theoretical calculations (from Transition State Theory). The reaction model of the process was studied by means of the master-plot method. Results obtained from experiments of thermolysis performed under the melting point temperature of N-(benzyl)-N´-(tert-butoxycarbonyl) sulfamide fit with an Avrami-Erofeev model whereas data found for experiments at higher temperatures fit with first order model. Isothermal experiments were simulated at 115, 120 and 130 oC using the model-free method, employing only the activation energy value.

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Gavernet, L.; Villalba, M. L.; Blanch, L. B.; Lick, I. D. Kinetic Study of Benzyl Sulfamide Synthesis by Thermolysis of N-(benzyl)-N´-(tert-Butoxycarbolyl) Sulfamide. Eur. J. Chem. 2013, 4, 44-48.

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Supporting Agencies

Agencia de Promocion Cientificay Tecnologica, CONICET, and Universidad Nacional de La Plata, Argentina
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