European Journal of Chemistry

Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives

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Published: Jun 30, 2013
DOI: https://doi.org/10.5155/eurjchem.4.2.153-156.751
Keywords:
Schiff base, Amoxicillin, Penicillin A, Azomethine, Imine derivatives, Antibacterial activity
Section
Research Article
Issue
Vol. 4 No. 2 (2013): June 2013
Dates
Received 2013-02-15
Accepted 2013-03-25
Published 2013-06-30


Main Article Content

Ivan Hameed Rouil Tomi
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Amer Hasan Abdullah
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Ali Hussein Raheemah Al-Daraji
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq
Selma Abdul Rudha Abbass
Department of Chemistry, College of Sciences, Al-Mustansiriya University, 10052, Baghdad, Iraq

Abstract

In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive (Staphylococcus aureus, Streptococcus faecalis) and two Gram negative (Escherichia coli, Pseudomonas aeruginosa) microorganisms in different concentrations (10-1, 10-3, 10-5 and 10-7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.

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How to Cite
(1)
Tomi, I. H. R.; Abdullah, A. H.; Al-Daraji, A. H. R.; Abbass, S. A. R. Synthesis, Characterization and Comparative Study the Antibacterial Activities of Some Imine-Amoxicillin Derivatives. Eur. J. Chem. 2013, 4, 153-156.

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References

[1]. Unal, A.; Palabiyik, L.; Karacan, E.; Onur, F. Turk. Pharm. Sci. 2008, 5, 1-16.

[2]. Bisson-Boutelliez, C.; Fontanay, S.; Finance, C., Kedzierewicz, F. AAPS Pharm. Sci. Tech. 2010, 11, 574-581.
http://dx.doi.org/10.1208/s12249-010-9412-1
PMid:20352533 PMCid:2902304

[3]. Jodeh, S.; Stati, H.; Haddad, M.; Renno, T.; Zaid, A.; Jaradat, N.; Kharoaf, M. Eur. J. Chem. 2012, 3(4), 480-484.
http://dx.doi.org/10.5155/eurjchem.3.4.480-484.698

[4]. Jodeh, S. Eur. J. Chem. 2012, 3(4), 468-474.
http://dx.doi.org/10.5155/eurjchem.3.4.468-474.706

[5]. Sivakumar, R.; Pradeepchandran, R. V.; Jayaveera, K. N. Eur. J. Chem. 2011, 2(4), 558-560.
http://dx.doi.org/10.5155/eurjchem.2.4.558-560.275

[6]. El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2(4), 539-543.
http://dx.doi.org/10.5155/eurjchem.2.4.539-543.55

[7]. Imran, M.; Iqbal, J.; Iqbal, S.; Ijaz, N. Turk. J. Biol. 2007, 31, 67-72.

[8]. Parekh, H. M.; Patel, M. N. Russian J. Coord. Chem. 2006, 32, 431-436.
http://dx.doi.org/10.1134/S1070328406060066

[9]. Singh, K.; Barwa, M. S.; Tyagi, P. Eur. J. Med. Chem. 2007, 42, 394-402.
http://dx.doi.org/10.1016/j.ejmech.2006.10.016
PMid:17224205

[10]. Bagihalli, G. B.; Avaji, P. G.; Patil, S. A.; Badami, P. S. Eur. J. Med. Chem. 2008, 43, 2639-2649.
http://dx.doi.org/10.1016/j.ejmech.2008.02.013
PMid:18395942

[11]. Naz, N.; Iqbal, M. Z. J. Chem. Soc. Pak. 2009, 31, 440-446.

[12]. Joshi, S.; Pawar, V.; Uma, V. Int. J. Pharm. Bio Sci. 2011, 2, 240-250.

[13]. Al-Garawi, Z. S. M.; Tomi, I. H. R.; Al-Daraji, A. H. R. E-Journal Chem. 2012, 9(2), 962-969.
http://dx.doi.org/10.1155/2012/218675

[14]. Tomi, I. H. R.; Al-Daraji, A. H. R.; Al-Qaysi, R. R. T.; Hasson, M. M.; Al-Dulaimy, K. H. Arabian J. Chem. 2011 http://dx.doi.org/10.1016/ j.arabjc.2010.12.003

[15]. Panda, S. S.; Chowdary. P.; Jayashree, B. S. Indian J. Pharm. Sci. 2009, 71(6), 684-687.
http://dx.doi.org/10.4103/0250-474X.59554
PMid:20376225 PMCid:2846477

[16]. Branch, S. K.; Casy, A. F.; Lipczynsky, A.; Ominde, E. M. A. Magn. Reson. Chem. 1986, 24, 465-479.
http://dx.doi.org/10.1002/mrc.1260240602

[17]. Branch, S. K.; Casy, A. F.; Ominde, E. M. A. J. Pharm. Biomed. Anal. 1987, 5, 73-103.
http://dx.doi.org/10.1016/0731-7085(87)80011-0

[18]. Kupka, T.; Dziegielewski, J. O.; Pasterna, G. J. Pharm. Biomed. Anal. 1993, 11, 103-116.
http://dx.doi.org/10.1016/0731-7085(93)80130-S

[19]. Stefano, R. D.; Scopelliti, M.; Pellerito, C.; Fiore, T.; Vitturi, R.; Colomba, M. S.; Gianguzza, P.; Stocco, G. C.; Consiglio, M.; Pellerito, L. J. Inorg. Biochem. 2002, 89, 279-292.
http://dx.doi.org/10.1016/S0162-0134(02)00366-5

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